Investigation of factors responsible for low oral bioavailability of cefpodoxime proxetil

International Journal of Pharmaceutics
Vasu Kumar KakumanuArvind Kumar Bansal

Abstract

Learning about the behavior of a drug in biological environment enables application of better formulation strategies to improve bioavailability of the same. Cefpodoxime proxetil (CP) is a prodrug, which is orally administered cephalosporin with only 50% absolute bioavailability. Despite previous studies, reasons responsible for low bioavailability of CP remain poorly understood. The present study tries to ascertain reasons for the low oral bioavailability of CP. The in vitro, in situ and ex vivo studies showed interesting results, where metabolism of CP into cefpodoxime acid (CA) inside the intestinal epithelial cell and preferential efflux of CA into lumen was identified as primary reason for low oral bioavailability of CP. Presence of specific carriers or transportation mechanism on the apical side membrane of enterocyte, than basal side of the same was observed.

Citations

Jul 8, 2010·Chemical & Pharmaceutical Bulletin·Yuan GaoJianjun Zhang
Mar 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Vasu Kumar KakumanuArvind Kumar Bansal
May 9, 2012·Drug Development and Industrial Pharmacy·Amrita BajajGhansham Munjapara
Dec 2, 2008·International Journal of Pharmaceutics·Junho ChuYoun-Woo Lee
Dec 21, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ji-Eon KimDae-Duk Kim
Feb 5, 2019·Expert Opinion on Drug Discovery·Anas Najjar, Rafik Karaman
Apr 29, 2020·Open Forum Infectious Diseases·Jennifer P CollinsLouise Francois Watkins
Nov 26, 2019·International Journal of Pharmaceutics·Yanliang FanChuanbin Wu
Aug 7, 2021·Infectious Diseases and Therapy·Balaji VeeraraghavanRani Diana Sahni

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