Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss

Archives of Dermatological Research
Rima NuwaihydRegina C Betz

Abstract

Female pattern hair loss (FPHL) is a common hair loss disorder in women and has a complex mode of inheritance. The etiopathogenesis of FPHL is largely unknown; however, it is hypothesized that FPHL and male pattern baldness [androgenetic alopecia (AGA)] share common genetic susceptibility alleles. Our recent findings indicate that the major AGA locus, an X-chromosome region containing the androgen receptor and the ectodysplasin A2 receptor (EDA2R) genes, may represent a common genetic factor underlying both early-onset FPHL and AGA. This gives further support for the widespread assumption of shared susceptibility loci for FPHL and AGA. However, we could not demonstrate association of further AGA risk loci, including 20p11, 1p36.22, 2q37.3, 7p21.1, 7q11.22, 17q21.31, and 18q21.1, with FPHL. Interestingly, a recent study identified four novel AGA risk loci in chromosomal regions 2q35, 3q25.1, 5q33.3, and 12p12.1. In particular, the 2q35 locus and its gene WNT10A point to an as-yet unknown involvement of the WNT signaling pathway in AGA. We hypothesized that the novel loci and thus also the WNT signaling may have a role in the etiopathogenesis of FPHL and therefore examined the role of these novel AGA risk loci in our FPHL samples...Continue Reading

References

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Citations

Dec 18, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M HarriesR Paus
Sep 8, 2016·International Journal of Trichology·Tee Wei SiahJerry Shapiro
Sep 17, 2015·Anais Brasileiros De Dermatologia·Paulo Müller Ramos, Hélio Amante Miot
Mar 8, 2017·Experimental Dermatology·Bruno A Bernard
Apr 30, 2017·Experimental Dermatology·Silke RedlerRegina C Betz
Jun 30, 2019·Journal of Cosmetic Dermatology·Michela StaraceBianca Maria Piraccini
Feb 5, 2016·Experimental Dermatology·Stefanie Heilmann-HeimbachMarkus M Nöthen
Mar 20, 2018·Archives of Dermatological Research·A Premanand, B Reena Rajkumari
Jun 30, 2021·The British Journal of Dermatology·B J DoolanJ A McGrath

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