Investigation of Gal-3 Expression Pattern in Serum and Cerebrospinal Fluid of Patients Suffering From Neurodegenerative Disorders

Frontiers in Neuroscience
Ghulam M Ashraf, Saleh S Baeesa

Abstract

We performed this study to investigate the possibility of a definitive pattern of Galectin-3 (Gal-3) expression in the cerebrospinal fluid (CSF) and serum of Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) patients. In our study, we collected the CSF and serum samples of 31 AD patients, 19 ALS patients and 50 normal healthy subjects (controls). Quantitative ELISA measured Gal-3 concentrations in CSF and serum samples. A comparative analysis was performed to analyze and understand the Gal-3 expression pattern. A number of neuropsychological assessments and statistical analyses were carried out to validate our findings. Recent researches have established the role of galectins in various neurodegenerative disorders (NDDs), but a definitive pattern of galectin expression is still elusive. A significant difference was observed in serum and CSF Gal-3 concentrations between AD patients and healthy controls. The difference in serum and CSF Gal-3 concentrations between ALS patients vs. controls was lesser as compared to AD patients vs. controls. The difference in serum and CSF Gal-3 concentrations of AD vs. ALS patients was not significant. The MMSE score and serum and CSF Gal-3 concentrations in AD and ALS patients, an...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1980·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·P A Fuld
Jan 1, 1997·International Psychogeriatrics·H Lehfeld, H Erzigkeit
Jan 5, 2000·Experimental Neurology·F Reichert, S Rotshenker
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 11, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
Nov 1, 2005·International Psychogeriatrics·Mariana K FlaksOrestes V Forlenza
Jan 9, 2007·Cancer Letters·Syed Saif HasanNaheed Banu
Feb 24, 2007·Journal of Bioenergetics and Biomembranes·Pratima Nangia-MakkerAvraham Raz
Jun 9, 2007·Biochemical and Biophysical Research Communications·Simon W F MokMichael Baier
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui-Rong JiangMiodrag L Lukic
May 7, 2009·Experimental Neurology·Marcelo Sampaio NarcisoAna Maria Blanco Martinez
Jul 15, 2009·Immunological Reviews·Neil C Henderson, Tariq Sethi
Feb 24, 2012·Journal of Alzheimer's Disease : JAD·Danilo Di BonaCalogero Caruso
Mar 16, 2012·Immunologic Research·Gordana RadosavljevicMiodrag L Lukic
Apr 25, 2012·Annals of the New York Academy of Sciences·Gabriel A RabinovichBrian A Cobb
May 2, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Joshua H K Tam, Stephen H Pasternak
Dec 21, 2012·The Journal of Infectious Diseases·Andrew W ChungDelphine J Lee
Jul 5, 2013·American Journal of Alzheimer's Disease and Other Dementias·Xuexin WangShouwei Yue
May 3, 2014·Neuroscience·Luca Peruzzotti-JamettiStefano Pluchino
Mar 28, 2012·Journal of Diabetes Investigation·Yasuhiko Yamamoto, Hiroshi Yamamoto
Jun 4, 2014·Journal of Neuroinflammation·Jonathan D CherryM Kerry O'Banion
Jul 2, 2014·Frontiers in Oncology·Anneliese Fortuna-CostaMauro S G Pavão
Aug 7, 2014·Tissue Barriers·Mireille ViguierFrédérique Deshayes
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Nov 13, 2014·Acta Neuropathologica Communications·Antonio Boza-SerranoTomas Deierborg
Jul 5, 2015·Experimental Biology and Medicine·Felipe L de OliveiraAndrea Doria
Oct 24, 2015·Parkinsonism & Related Disorders·Ajenthan SurendranathanJohn T O'Brien
May 27, 2016·Glia·Gwenn A Garden, Brian M Campbell
Sep 10, 2016·PloS One·Patrik Maximilian BauerUlrica Englund-Johansson
Nov 10, 2016·Cell Metabolism·Marie SiwickiMikael J Pittet
Nov 24, 2016·Oncotarget·Mariana RinaldiLaura A Pasquini

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Citations

Oct 18, 2019·Current Neuropharmacology·João Ronielly Campêlo AraújoAna Cristina de Oliveira Monteiro-Moreira
Jan 31, 2020·The Journal of Biological Chemistry·Tsuneyoshi SekiTatsushi Toda
Aug 28, 2020·Acta neurologica Belgica·Tamer YazarMurat Cihan
Jun 26, 2020·Frontiers in Cellular Neuroscience·Mar PuigdellívolGuy C Brown
Sep 1, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hülya Olgun YazarMurat Cihan
Mar 19, 2021·Medicinal Research Reviews·Reza RahimianJasna Kriz

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Methods Mentioned

BETA
ELISA

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