Investigation of gene expression and serum levels of PIN1 and eNOS with high blood pressure in patients with Alzheimer disease

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Mina AzimiAlireza Nourazarian

Abstract

According to evidence, Alzheimer's disease is known as one of the most serious neurodegenerative diseases, for which hypertension has been observed to be a key risk factor. Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer's disease sufferers. Blood samples were obtained from subjects who were divided into four groups: the control group, normotensive Alzheimer's patients, the Alzheimer's sufferers group with hypertension, and the healthy group with only hypertension, considering the inhibition of confounding factors. Thereafter, eNOS and PIN1 genes expression along with serum levels were studied. Based on the obtained results, a statistically significant correlation didn't exist between serum level of PIN1 and the systolic and diastolic blood pressure, between serum level of eNOS and diastolic blood pressure in the norm tension Alzheimer's disease patients, between serum levels of PIN1, eNOS and systolic blood pressure, and between serum eNOS and systolic and diastolic blood pressure in the patients with hypertension (p<0.05). According to the results obtained from this study, measuring the serum levels of eNOS and Pin1 may co...Continue Reading

References

Jan 23, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kun Ping LuInez Vincent
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 11, 2005·Neurobiology of Aging·Amy R BorensteinEric B Larson
Nov 2, 2005·The Journal of Experimental Medicine·Carl NathanM Flint Beal
Dec 22, 2005·Blood·Petra KleinbongardMalte Kelm
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·David M DudzinskiThomas Michel
Jul 15, 2006·Journal of Molecular and Cellular Cardiology·Peter F MountDavid A Power
Jul 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giti GarthwaiteJohn Garthwaite
Sep 2, 2006·Journal of Neurochemistry·D Allan ButterfieldRukhsana Sultana
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel A Hopper, John Garthwaite
Nov 11, 2006·Circulation Research·Frank M Faraci
Feb 24, 2007·Biochimica Et Biophysica Acta·Martin BalastikKun Ping Lu
Feb 22, 2008·Current Alzheimer Research·Mahshid ForoughanMehrdad Sheikhvatan
Aug 4, 2011·Hypertension·Valorie L ChiassonBrett M Mitchell
Aug 22, 2012·Cold Spring Harbor Perspectives in Medicine·Richard Mayeux, Yaakov Stern
May 25, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Katherine C WoodMark T Gladwin
Jun 12, 2013·Journal of Neurochemistry·Susan A AustinZvonimir S Katusic
Jun 22, 2014·Biological Psychiatry·Celeste M Karch, Alison M Goate

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.