Investigation of heart rate and blood pressure variability, baroreflex sensitivity, and approximate entropy in acute brain injury patients

Journal of Critical Care
Vasilios PapaioannouMaria Giala

Abstract

The purpose of the study was to investigate longitudinally over time heart rate (HR) and blood pressure variability and baroreflex sensitivity in acute brain injury patients and relate them with the severity of neurologic dysfunction and outcome. Data from 20 brain injured patients due to multiple causes and treated in the intensive care unit were used, with HR and blood pressure recorded from monitors and analyzed on a daily basis. We performed power spectral analysis estimating low frequencies (LF: 0.04-0.15 Hz), high frequencies (HF: 0.15-0.4 Hz), and their ratio and calculated the approximate entropy, which assesses periodicity within a signal and transfer function (TF), that estimates baroreflex sensitivity. Heart rate variance was considered as a measure of HR variability. Nonsurvivors (brain dead) had lower approximate entropy (0.65 +/- 0.24 vs 0.84 +/- 0.26, P < .05) and lower variance mean values (0.48 +/- 0.54 vs 1.29 +/- 0.42 ms(2)/Hz, P < .01), lower LF and HF minimum values (0.31 +/- 0.88 vs 1.11 +/- 0.46, P < .01; and 0.27 +/- 0.42 vs 0.86 +/- 0.30, P < .01, respectively), lower LF/HF (0.22 +/- 0.29 vs 0.62 +/- 0.28, P < .01), and lower TF mean values (0.43 +/- 0.29 vs 1.11 +/- 0.74, P < .05) during their whole st...Continue Reading

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Citations

Feb 26, 2011·Anesthesiology Research and Practice·Mark L RyanKenneth G Proctor
Sep 6, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mervyn Singer, Michael A Matthay
Sep 29, 2009·Journal of Critical Care·Shunji KasaokaTsuyoshi Maekawa
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