Investigation of immunohistochemical ERα, ERβ and ERβcx expressions in normal and neoplastic breast tissues

Pathology, Research and Practice
Kemal Kürşat Bozkurt, Nilgün Kapucuoğlu

Abstract

Estrogen receptor alpha (ERα) is a well-established prognostic marker in breast cancer. The role of estrogen receptor beta (ERβ) in breast cancers is still under investigation. We aimed to investigate the clinicopathological significance and immunohistochemical expression patterns of ERα, total ERβ (ERβ) and its spliced variant ERβcx in normal breast, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). Our study population comprised 10 normal breasts, 26 DCISs and 44 IDCs. Immunohistochemical expression of these markers was investigated in sections of formalin-fixed, paraffin-embedded blocks by 2 observers. In invasive ductal carcinomas, ERβ expression had a significant positive correlation with ERα expression (p=0.013), while ERβcx expression was significantly associated with the presence of lymphovascular invasion (p=0.046). There was a significant relationship between ERα expression and low histological grade (p<0.0001). Similarly, ERα+/ERβ+ tumors (p=0.004) and ERα+/ERβcx+ tumors (p=0.008) were significantly associated with low histological grade, too. ERα expression (p=0.009), ERβcx expression (p=0.048) and ERα+/ERβ+ coexpression (p=0.002) increased significantly in progression from normal breast to invasi...Continue Reading

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Citations

Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·Nuiki Iota ChantziMuichael N Alexis
Feb 11, 2015·Pathology, Research and Practice·Norbert Nass, Thomas Kalinski
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Bo HuangJan-Åke Gustafsson
Jun 26, 2013·Medical Oncology·Ana BožovićVesna Mandušić
Jun 11, 2020·Cancers·Assunta SellittoFrancesca Rizzo
Mar 16, 2021·Breast Cancer : Basic and Clinical Research·Manar G ShalabiAbozer Y Elderdery

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