Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Pin-Chun ChaoKai-Chun Cheng

Abstract

Animal models are widely used to develop drugs for treating diabetes mellitus (DM). Insulin resistance (IR) is one of the main problems in type-2 DM (T2DM). Streptozotocin (STZ) is used to damage pancreatic cells for induction of DM. Many rat models were applied in research as T2DM. However, the degree of IR in each model is unknown. In the present study, IR and insulin signaling were compared in four models of type 2 diabetes: rats fed a fructose-rich chow for 8 weeks, rats feed high-fat chow for 4 weeks followed by injection with streptozotocin (35 mg/kg, i.p.), rats injected with a single low dose streptozotocin (45 mg/kg, i.p.), and rats injected with a single dose of nicotinamide followed by a single high dose of streptozotocin (60 mg/kg, i.p.). Values from these determinations in diabetic rats showing the order that insulin resistance is most marked in rats received fructose-rich chow followed by high-fat diet before STZ injection induced model (HFD/STZ rats), and rats injected with low dose of STZ but it is less marked in rats induced by nicotinamide and STZ. Additionally, insulin secretion was reduced in three rat models except the rats receiving fructose-rich chow. Western blots also showed the same changes in phosphor...Continue Reading

References

Aug 26, 1998·Developmental Immunology·M L LukićA Shahin
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J A PethE J Henriksen
Nov 25, 2000·Metabolism: Clinical and Experimental·M J ReedG M Reaven
Feb 13, 2001·Environmental Toxicology and Pharmacology·M ItoA Naruse
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE
Oct 24, 2003·American Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·Takayuki MatsumotoKatsuo Kamata
Jun 28, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K SrinivasanP Ramarao
Aug 17, 2006·Journal of Basic and Clinical Physiology and Pharmacology·Ramalingam Saravanan, Leelavinothan Pari
May 22, 2007·Metabolism: Clinical and Experimental·Jen-Der LinHsiao-Fen Weng
Jan 29, 2008·Current Diabetes Reviews·Lucia Gagliardi, Gary Wittert
Oct 18, 2008·Diabetes, Obesity & Metabolism·J RahierJ C Henquin
Feb 12, 2011·Phytotherapy Research : PTR·Yi-Jui ChiuShih-Hsiang Lo
May 4, 2011·World Journal of Diabetes·Vandana Saini
Feb 9, 2013·Advances in Experimental Medicine and Biology·Kouidhi Soumaya
Apr 16, 2013·Islets·Ahter D SanliogluSalih Sanlioglu
Jul 31, 2013·Archives of Pharmacal Research·Tae-Young HaJae-Keol Rhee
Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
May 2, 2014·Current Atherosclerosis Reports·Francesco PaneniFrancesco Cosentino
Nov 21, 2014·Journal of Diabetes Investigation·Søs Skovsø
Sep 4, 2015·Current Protocols in Pharmacology·Brian L Furman
Aug 23, 2016·Journal of Diabetes Research·Ahlke Heydemann
Sep 19, 2016·Pharmacological Reports : PR·Sangeeta Pilkhwal SahAnil Kumar

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Citations

May 29, 2020·Journal of Food Biochemistry·Jayasindu Mathiyazhagan, Gothandam Kodiveri Muthukaliannan
Jul 22, 2020·BMJ Open Diabetes Research & Care·Sebastian MaciakHalina Car
Dec 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mónica Ríos-SilvaMiguel Huerta
Apr 11, 2020·Respiratory Research·Roberta SüdyFerenc Peták
Oct 29, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Eman D MohammedBeicheng Sun
Jan 6, 2021·Acta histochemica·Maggie E AmerMohamed A El-Missiry
Nov 4, 2020·Toxicology Mechanisms and Methods·Oluwafemi Ezekiel KaleOdutola Osilesi
Apr 6, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ke SuCheng Chen
Apr 28, 2021·Current Protocols·Brian L Furman
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chien-Hui WuGuo-Jane Tsai

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