Investigation of interfraction variations of MammoSite balloon applicator in high-dose-rate brachytherapy of partial breast irradiation

International Journal of Radiation Oncology, Biology, Physics
Yongbok KimMoyed Miften

Abstract

To measure the interfraction changes of the MammoSite applicator and evaluate their dosimetric effect on target coverage and sparing of organs at risk. A retrospective evaluation of the data from 19 patients who received 10 fractions (34 Gy) of high-dose-rate partial breast irradiation was performed. A computed tomography-based treatment plan was generated for Fraction 1, and a computed tomography scan was acquired just before the delivery of each fraction to ensure a consistent shape of the balloon. The eccentricity, asymmetry, and planning target volume (PTV) for plan evaluation purposes (PTV_EVAL), as well as trapped air gaps, were measured for all patients. Furthermore, 169 computed tomography-based treatment plans were retrospectively generated for Fractions 2-10. Interfraction dosimetric variations were evaluated using the %PTV_EVAL coverage, target dose homogeneity index, target dose conformal index, and maximum doses to the organs at risks. The average variation of eccentricity and asymmetry from Fraction 1 values of 3.5% and 1.1 mm was -0.4% +/- 1.6% and -0.1 +/- 0.6 mm. The average trapped air gap volume was dramatically reduced from before treatment (3.7 cm(3)) to Fraction 1 (0.8 cm(3)). The PTV_EVAL volume change wa...Continue Reading

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Citations

Jan 27, 2010·The Journal of Biological Chemistry·Antonio VerdolivaRita De Santis
Apr 29, 2010·Cancer Biotherapy & Radiopharmaceuticals·Rita De SantisPaolo Carminati
Feb 5, 2010·Journal of Biomedicine & Biotechnology·Rita De SantisCarlo Antonio Nuzzolo
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Céline BourgierHugo Marsiglia
Aug 3, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C BourgierH Marsiglia
Dec 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian KirisitsFrank-André Siebert
Aug 19, 2010·Journal of Applied Clinical Medical Physics·Yongbok KimMoyed Miften
Aug 19, 2010·Journal of Applied Clinical Medical Physics·Yongbok KimMoyed Miften

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