Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1

Human Immunology
Iris A HalfpennyFionnuala Williams

Abstract

The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies within this Caucasian population. Additionally, cell line DNA and CEPH families, both from the 13th International Histocompatibility Workshop, and local families have been investigated. The generated data emphasize the complexity and highly polymorphic nature of this KIR gene complex; 11 allelic variations were identified, 2 of which are novel to this study. Use of the PCR-SSOP system has confirmed the presence of multiple copies of KIR3DL1/S1 alleles in a number of individuals.

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaJ L Strominger
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Jun 1, 2002·Human Immunology·Katia GagneJean Denis Bignon
Sep 10, 2002·Transplant Immunology·Derek MiddletonLynne Maxwell
Jun 14, 2003·Critical Reviews in Immunology·Makoto YawataPeter Parham
Jul 3, 2003·Immunogenetics·C A GarciaS G E Marsh
Jul 16, 2003·Tissue Antigens·S G E MarshH Wain

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Citations

Jan 4, 2007·Immunogenetics·D MiddletonP A Gourraud
Feb 19, 2005·Nature Reviews. Immunology·Peter Parham
Jun 13, 2013·Critical Reviews in Immunology·Geraldine M O'Connor, Daniel McVicar
May 11, 2010·Immunogenetics·Colum McErleanDerek Middleton
Dec 24, 2009·Immunology·Derek Middleton, Faviel Gonzelez
Feb 5, 2010·Arthritis and Rheumatism·Roberto Díaz-PeñaCarlos López-Larrea
May 19, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeanette E BoudreauKatharine C Hsu
Mar 1, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jesse BruijnesteijnRonald E Bontrop
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabrina B TanerFrances M Brodsky
Feb 16, 2007·European Journal of Immunology·Anita TrundleyJohn Trowsdale
Jun 6, 2017·Frontiers in Immunology·Bercelin ManiangouKatia Gagne

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