Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies

Journal of the Neurological Sciences
Ryoko YamamotoHeii Arai

Abstract

We examined 19 autopsied cases of dementia with Lewy bodies (DLB) using pathological and alpha-synuclein-immunohistochemical methods, and investigated Lewy pathology in the primary visual pathway (lateral geniculate body and Brodmann's area 17), secondary visual pathway (pulvinar, Brodmann's areas 18 and 19, and inferior temporal cortex), amygdala and substantia nigra, to clarify the relationship between visual misidentification and Lewy pathology in the visual pathway. Consequently, the secondary visual pathway revealed significantly severer Lewy pathology than the primary visual pathway, suggesting that the degeneration of the secondary visual pathway induces dysfunction in the recognition of objects shape and color. In addition, the amygdala revealed significantly severer Lewy pathology and neuronal loss than the primary and secondary visual pathways, suggesting that the degeneration of the amygdala, which receives the afferent connections from the substantia nigra, fails to modulate the visual processing according to cognition and emotion. These findings suggest that Lewy pathologies in the secondary visual pathway and amygdala may cause the dysfunction of the visuo-amygdaloid pathway and participate in visual misidentifica...Continue Reading

References

Jan 13, 2000·Trends in Neurosciences·K L GrieveJ Cudeiro
Feb 15, 2002·Brain : a Journal of Neurology·A J HardingG M Halliday
Mar 19, 2002·Journal of the Neurological Sciences·Wami MaruiKenji Kosaka

❮ Previous
Next ❯

Citations

Feb 13, 2013·Translational Neurodegeneration·Yue Huang, Glenda Halliday
Jul 18, 2014·Current Neurology and Neuroscience Reports·Sana SuriNicola Filippini
Apr 26, 2014·Brain : a Journal of Neurology·Nico J DiederichChristopher G Goetz
Dec 18, 2012·Journal of Neuropathology and Experimental Neurology·Elizabeta B Mukaetova-LadinskaIan G McKeith
Nov 15, 2008·NMR in Biomedicine·Miho OtaTakashi Asada
Mar 31, 2011·Journal of Magnetic Resonance Imaging : JMRI·Koji KamagataNobutaka Hattori
Feb 20, 2015·International Journal of Geriatric Psychiatry·Taku YoshidaShu-ichi Ueno
Feb 23, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Cristina Sanchez-CastanedaCarme Junque
Nov 13, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Ji E LeePhil Hyu Lee
Mar 5, 2015·Journal of Parkinson's Disease·Jasmin RahimiGabor G Kovacs
May 15, 2015·Neuropathology and Applied Neurobiology·Daniel ErskineAhmad Adam Khundakar
Aug 13, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stefano Delli PizziLaura Bonanni
Dec 23, 2014·International Psychogeriatrics·Elizabeta B Mukaetova-Ladinska
May 26, 2016·Journal of the International Neuropsychological Society : JINS·Micaela MitoloDavid P Salmon
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Douglas W ScharreMaria Kataki
Jan 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel ErskineAhmad A Khundakar
Apr 8, 2011·Journal of Geriatric Psychiatry and Neurology·Joshua S WoodJohn T O'Brien
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel ErskineChristopher M Morris
Dec 7, 2019·Journal of Geriatric Psychiatry and Neurology·Akira KuritaMegumi Suzuki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.