PMID: 11920855Mar 29, 2002Paper

Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia

American Journal of Medical Genetics
S G SchwabDieter B Wildenauer

Abstract

The hypothesis that HLA antigens confer susceptibility to schizophrenic disorders has been tested by studying linkage and association in a family sample with 69 sib-pair families. Suggestive evidence for linkage was obtained by nonparametric multipoint LOD score analysis with a maximum around DQB CAR (P = 0.0004), a microsatellite marker that is in linkage disequilibrium with the HLA antigen DQB1. Spurious evidence for negative association as calculated by the transmission disequilibrium test was found for HLA- DRB1*11 (chi-square = 11.72, corrected P value = 0.03) and for the haplotype DQB1*301-DQA1*501-DRB1*11 (chi-square = 11.3, corrected P value = 0.043). No evidence of association with these alleles was obtained in a sample of 89 trios with schizophrenic offspring and parents. Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31.

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Citations

Feb 27, 2008·European Archives of Psychiatry and Clinical Neuroscience·Jung Jin KimTae-Youn Jun
Nov 19, 2003·Schizophrenia Research·Sibylle G SchwabDieter B Wildenauer
Jul 4, 2003·Psychiatry and Clinical Neurosciences·Chi-Un PaeAlessandro Serretti
Mar 11, 2004·Psychiatry and Clinical Neurosciences·Naoshi KanekoToshiyuki Someya
Aug 7, 2008·Pharmacogenomics·Carolin Opgen-Rhein, Michael Dettling
Jul 31, 2013·Cell Stress & Chaperones·Malgorzata KowalczykJan Kowalski
Nov 30, 2013·Biological Psychiatry·Akiko Hayashi-TakagiKazuya Iwamoto
Jul 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monojit DebnathGanesan Venkatasubramanian
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Steven MatthysseJosef Parnas
Apr 5, 2011·Psychiatry Research·Bisu SinghTapas Kumar Chaudhuri
May 28, 2008·Pharmacotherapy·Carroll-Ann W Goldsmith, Donald P Rogers
Oct 6, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Stephen J GlattMing T Tsuang
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Urs MeyerBenjamin K Yee
Apr 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·William G Johnson
Nov 24, 2006·Genetic Epidemiology·Ren-Hua ChungEden R Martin
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·B MorarD B Wildenauer
Dec 24, 2008·Expert Review of Neurotherapeutics·Donald P Rogers, Carroll-Ann W Goldsmith
Jul 23, 2020·International Journal of Immunogenetics·Vani SeshasubramanianSrinivasan Periathiruvadi
Nov 30, 2011·International Journal of Psychiatry in Clinical Practice·Saeed KadasahMohammad Tariq

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