Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse.

Genetics
Marie O'SheaSarah E Lloyd

Abstract

The genetic basis of prion disease incubation time is principally determined by polymorphisms in the prion protein gene, Prnp. However, it is now known that other genetic factors are important. Several quantitative trait loci (QTL) have been identified across the genome including a broad region of linkage on Mmu11. Monocyte chemoattractant protein 1 (MCP-1) maps to this region and has been associated with microglial activation and reduced survival in the ME7 mouse scrapie model of prion disease. We have identified 10 polymorphisms, 3 of which are nonsynonomous, in Mcp1 between "long" (CAST) and "short" (SJL or NZW) incubation-time mouse strains. Crosses between these strains and Mcp1(-/-) mice inoculated with the Chandler/RML mouse scrapie prion strain formed the basis of a quantitative complementation test. In these models loss of Mcp1 did not show an increase in incubation time suggesting that the effects of Mcp1 may be specific to the ME7 prion strain and that Mcp1 does not contribute to the QTL described on Mmu11.

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Citations

Jul 21, 2010·Acta Neuropathologica·V Hugh Perry
Nov 6, 2013·Nature Reviews. Immunology·Adriano AguzziCaihong Zhu
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Julia GrizenkovaSarah E Lloyd
Jul 27, 2010·Pharmacogenetics and Genomics·Chris DowningThomas E Johnson
Jan 15, 2013·International Journal of Hepatology·Cecilia Ying Ju SungHani El-Nezami
Oct 24, 2012·Bone Marrow Research·Aleksandra Klimczak, Andrzej Lange
Dec 17, 2011·PloS One·Shaheen AkhtarSarah E Lloyd
Jan 26, 2013·PloS One·Shaheen AkhtarSarah E Lloyd
Mar 25, 2014·BMC Neuroscience·Julia GrizenkovaSarah E Lloyd
Mar 1, 2014·Prion·Dilshan S HarischandraAnumantha G Kanthasamy
Jul 18, 2017·The Journal of Clinical Investigation·Adriano Aguzzi, Caihong Zhu
Jan 18, 2019·Viruses·James A Carroll, Bruce Chesebro
Jul 12, 2017·Frontiers in Aging Neuroscience·Juliane ObstDiego Gomez-Nicola
Sep 21, 2019·Annual Review of Genetics·Simon MeadJohn Collinge
Mar 7, 2021·International Journal of Molecular Sciences·Bei LiCaihong Zhu

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