PMID: 7540165Feb 1, 1995Paper

Investigation of mechanisms influencing the accumulation of ultrasmall superparamagnetic iron oxide particles in lymph nodes

Investigative Radiology
A MühlerH J Weinmann

Abstract

The current study was designed to investigate the lymph node accumulation mechanisms of dextran-coated ultrasmall superparamagnetic iron oxide particles (USPIO) in rats. The iron deposition in the lymph nodes after intravenous administration of USPIO at a dose of 200 mumol Fe/kg was measured in vitro by inductively coupled plasma atomic emission spectrometer in control rats, in rats after depletion of complement C3, after induction of antidextran antibodies, and with prior ligation of afferent lymphatic vessels. The results were correlated with baseline iron concentration and histology. A significant increase in iron concentration but unequal distribution between central and peripheral nodes occurred after administration of USPIO in rats. Much less accumulation was observed in guinea pigs. In rats, the nodal uptake of USPIO was not impaired by depletion of complement C3 using cobra venom factor. The central lymph nodes (mesenteric nodes) showed significantly more accumulation of iron particles in the presence of antidextran antibodies induced by dextran preimmunization. Afferent lymphatic vessel ligation did not effect iron particle accumulation. Accumulation of USPIO in lymph nodes is largely species-dependent but is independe...Continue Reading

Citations

Mar 17, 2010·Chemical Reviews·Angelique Louie
May 15, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mukesh G HarisinghaniPeter F Hahn
May 28, 2004·Radiology·Bernd MisselwitzHanns-Joachim Weinmann
Jul 13, 2005·European Journal of Haematology. Supplementum·Axel GossmannKlaus-Jürgen Lackner
Oct 1, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Gunnar SchützHubertus Pietsch
Feb 9, 2006·European Journal of Radiology·Patrick Wunderbaldinger
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick WunderbaldingerRalph Weissleder
Jul 2, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seung Hong Choi, Woo Kyung Moon
Oct 5, 2001·Journal of Computer Assisted Tomography·M G HarisinghaniP F Hahn
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·B E Van BeersA M Smith

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