Investigation of medical effect of multiple ketamine infusions on patients with major depressive disorder

Journal of Psychopharmacology
Wei ZhengYu-Ping Ning

Abstract

Single-dose intravenous ketamine has rapid but time-limited antidepressant effects. We aimed to examine the sustained effects of six consecutive ketamine infusions in Chinese patients with major depressive disorder. Seventy-seven patients with major depressive disorder were eligible to receive augmentation with six ketamine infusions (0.5 mg/kg over 40 min) administered over the course of 12 days (Monday-Wednesday-Friday). The coprimary outcome measures were the rates of response and remission as measured on the 10-item Montgomery-Asberg Depression Rating Scale. Psychotomimetic and dissociative symptoms were measured with the Brief Psychiatric Rating Scale-positive symptoms and the Clinician Administered Dissociative States Scale, respectively. After the first ketamine infusion, only 10 (13.0%) and 6 (7.8%) patients responded and remitted, respectively; after six ketamine infusions, 52 (67.5%) patients responded and 37 (48.1%) remitted. There was a significant mean decrease in Montgomery-Asberg Depression Rating Scale score at four hours after the first ketamine infusion (7.0±7.5, p<0.001), and this decrease was maintained for the duration of the infusion period. The response to ketamine treatment was positively associated with...Continue Reading

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Citations

Dec 5, 2019·Current Psychiatry Reports·Aiste LengvenytePhilippe Courtet
Jun 23, 2020·Expert Opinion on Drug Discovery·Laura Perez-CaballeroEsther Berrocoso
Jul 2, 2020·Neuropsychiatric Disease and Treatment·Wei ZhengXiong Huang
Apr 21, 2020·Neuropsychiatric Disease and Treatment·Xing-Bing HuangYuping Ning
May 27, 2021·Therapeutic Advances in Psychopharmacology·Wei ZhengYu-Ping Ning
Jun 6, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anna FeeneyGeorge I Papakostas

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