PMID: 15332630Aug 31, 2004Paper

Investigation of microstructural features in regenerating bone using micro computed tomography

Journal of Materials Science. Materials in Medicine
Anthony C JonesBruce Milthorpe

Abstract

We illustrate some of the uses of micro-computed tomography (micro-CT) to study tissue-engineered bone using a micro-CT facility for imaging and visualizing biomaterials in three dimensions (3-D). The micro-CT is capable of acquiring 3D X-ray CT images made up of 2000(3) voxels on specimens up to 5 cm in extent with resolutions down to 2 microm. This allows the 3-D structure of tissue-engineered materials to be imaged across orders of magnitude in resolution. This capability is used to examine an explanted, tissue-engineered bone material based on a polycaprolactone scaffold and autologous bone marrow cells. Imaging of the tissue-engineered bone at a scale of 1 cm and resolutions of 10 microm allows one to visualize the complex ingrowth of bone into the polymer scaffold. From a theoretical viewpoint the voxel data may also be used to calculate expected mechanical properties of the tissue-engineered implant. These observations illustrate the benefits of tomography over traditional techniques for the characterization of bone morphology and interconnectivity. As the method is nondestructive it can perform a complimentary role to current histomorphometric techniques.

Citations

Feb 6, 2007·Journal of Periodontology·Chan Ho ParkWilliam V Giannobile
Dec 20, 2005·Journal of Materials Science. Materials in Medicine·J S CapesR E Cameron
Jan 8, 2009·Clinical Oral Implants Research·Marcus KleinHeinz Duschner
Feb 29, 2008·Biotechnology and Bioengineering·J V NygaardF Besenbacher
Mar 6, 2007·Biomaterials·Anthony C JonesMark A Knackstedt
Jul 21, 2006·The British Journal of Oral & Maxillofacial Surgery·Candan EfeogluAylin Sipahi
Sep 13, 2014·Journal of Dental Research·C H ParkY J Seol
Feb 27, 2008·Chemical Reviews·Aranzazu del Campo, Eduard Arzt
Jun 17, 2020·ACS Applied Materials & Interfaces·Shengbo GeChristian Sonne

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