Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response

The International Journal of Neuropsychopharmacology
Laura M FioriGustavo Turecki

Abstract

Major depressive disorder is a debilitating illness, which is most commonly treated with antidepressant drugs. As the majority of patients do not respond on their first trial, there is great interest in identifying biological factors that indicate the most appropriate treatment for each patient. Studies suggest that microRNA represent excellent biomarkers to predict antidepressant response. We investigated the expression of miR-1202, miR-135a, and miR-16 in peripheral blood from 2 cohorts of depressed patients who received 8 weeks of antidepressant therapy. Expression was quantified at baseline and after treatment, and its relationship to treatment response and depressive symptoms was assessed. In both cohorts, responders displayed lower baseline miR-1202 levels compared with nonresponders, which increased following treatment. Ultimately, our results support the involvement of microRNA in antidepressant response and suggest that quantification of their levels in peripheral samples represents a valid approach to informing treatment decisions.

References

Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Jan 1, 2011·Translational Psychiatry·J M LaunayO Kellermann
Oct 17, 2013·PloS One·Manami HondaKazuhito Rokutan
Feb 18, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yogesh Dwivedi
Dec 3, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dariusz ZurawekMarta Dziedzicka-Wasylewska
Sep 2, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erin K KirschmannMary M Torregrossa
Sep 14, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heather Trantham-DavidsonL Judson Chandler

❮ Previous
Next ❯

Citations

Dec 1, 2017·Frontiers in Molecular Neuroscience·Dorota WyczechowskaFrancesca Peruzzi
Apr 28, 2018·Expert Review of Molecular Diagnostics·Cristina MoraAnnamaria Cattaneo
Apr 26, 2019·Frontiers in Genetics·Janise N KuehnerBing Yao
Jul 28, 2019·Journal of Neural Transmission·Nicola LopizzoAnnamaria Cattaneo
Jun 6, 2020·Frontiers in Psychiatry·Maria Salud García-GutiérrezJorge Manzanares
Oct 28, 2017·Current Opinion in Psychiatry·Juan Pablo LopezGustavo Turecki
Mar 1, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chenggui Miao, Jun Chang
Aug 21, 2021·Journal of Neural Transmission·Helena Kyunghee KimStefan Kloiber
Aug 23, 2021·Translational Psychiatry·Laura M FioriGustavo Turecki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.