Investigation of orofacial stem cell niches and their innervation through microfluidic devices

European Cells & Materials
P PagellaT A Mitsiadis

Abstract

Stem cell-based mediated therapies represent very promising approaches for tissue regeneration and are already applied with success in clinics. These therapeutic approaches consist of the in vitro manipulation of stem cells and their consequent administration to patients as living and dynamic biological agents. Nevertheless, the deregulation of stem cells function might result in the generation of pathologies such as tumours or accelerated senescence. Moreover, different stem cells sources are needed for regeneration of specific tissues. It is thus fundamental to understand the mechanisms regulating the physiology of stem cells. Microfluidic technology can be used to mimic in vivo scenarios and allow the study of stem cell physiology at both single cell and whole stem cell niche levels.This review focuses on the potential sources of stem and progenitor cells for orofacial regeneration and the use of microfluidic technologies for the study of stem cells behaviour and stem cell niches, in the light of regenerative medicine.

Citations

Sep 8, 2017·Advanced Healthcare Materials·Tatsuya OsakiRoger D Kamm
May 5, 2018·Tissue Engineering. Part B, Reviews·Valérie OrtiIvan Panayotov
Dec 12, 2019·PeerJ·Marytere Guerrero-JiménezBeatriz A Rodas-Junco
Sep 7, 2016·Frontiers in Physiology·Thimios A Mitsiadis, Giovanna Orsini
Sep 21, 2016·Stem Cells International·Shayee MiranPierfrancesco Pagella
Aug 19, 2016·Frontiers in Physiology·Thimios A Mitsiadis, Pierfrancesco Pagella
Jun 15, 2017·Frontiers in Physiology·Thimios A MitsiadisLucia Jimenez-Rojo
Feb 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pierfrancesco PagellaThimios A Mitsiadis
Feb 6, 2017·Frontiers in Physiology·Despoina NatsiouLucia Jimenez-Rojo
Apr 4, 2021·International Journal of Molecular Sciences·Pierfrancesco PagellaThimios A Mitsiadis
Aug 6, 2018·Biochimie·Anne BaudryOdile Kellermann
May 18, 2021·IScience·Pierfrancesco PagellaThimios A Mitsiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.