Investigation of pharmaceutically active compounds in an urban receiving water: Occurrence, fate and environmental risk assessment

Ecotoxicology and Environmental Safety
Jianchao LiuZhenhua Yan

Abstract

Pharmaceutically active compounds (PhACs) recently have been recognized to constitute a health risk for aquatic ecosystems. The major pathways of PhACs to enter the aquatic environment are excretion and discharge of effluents through sewage treatment plants (STPs). The occurrence, bioaccumulation and risk assessment of lipophilic PhACs, including erythromycin, ketoconazole, indomethacin, diclofenac, gemfibrozil, bezafibrate, propranolol, carbamazepine, sertraline and 17α-ethinylestradiol were investigated in a river that receives effluents from STP. The results indicate that the PhACs were extensively existed in fish, sediment, suspended particulate matter (SPM), colloidal phase (5 kDa to 1 µm) and truly dissolved phase (< 5 kDa) water, with total concentration of ten PhACs (Σ10PhACs) of ND-19.6 ng/g, 7.3-11.2 ng/g, 25.3-101.5 ng/g, 10.1-27.7 ng/L and 67.0-107.6 ng/L, respectively. The Σ10PhACs for particulate and water samples collected from STP's outfall site were higher than those collected from upstream and downstream, indicating that the STP is an important PhACs source of river. However, the Σ10PhACs in sediment showed no significant statistical differences in the sampling area, and which was 3.5-9.5 times lower than thos...Continue Reading

Citations

Sep 11, 2019·International Journal of Environmental Research and Public Health·Chaoya ZhengQing Chen
Feb 26, 2020·Journal of Environmental Management·Jianchao LiuZhenhua Yan
Apr 7, 2021·Environmental Monitoring and Assessment·Luiza C G M TeixeiraSérgio F Aquino
Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniele Sadutto, Yolanda Picó

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