PMID: 7016983Mar 1, 1981Paper

Investigation of proteinases in the digestive tract using 4-methoxy-2-naphthylamine (MNA) substrates

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
R Gossrau

Abstract

Aminopeptidase (AP) A, B, and M, gamma-glutamyltranspeptidase (GGT), endopeptidase I and II, membrane-associated endopeptidase I and II, dipeptidylaminopeptidase (DAP) I, II, and IV, trypsin and chymotrypsin were investigated with 4-methoxy-2-naphthylamine (MNA) substrates and ester proteinases with n-acetyl-L-methionine-1-naphthylester as substrate in the digestive tract of laboratory rodents. Biochemically, proteinases and ester proteinases show different activities in the salivary glands, esophagus, stomach, liver, pancreas, duodenum jejunum, ileum, and colon; sex differences in proteinase and ester proteinase activity were measured, especially in the submandibular gland of rats and mice. Histochemically these enzymes are preferentially localized in surface membranes, lysosomes, secretion granules, and Golgi apparatus of cells of the endocrine and exocrine secretory system, resorptive system and immune system of the digestive tract. Besides the general occurrence of lysosomal (DAP I and II, single cell types and functional units of these systems possess their own individual proteinase and ester proteinase equipment. The cells of the granulated tubules of rat and mouse submandibular gland contain endopeptidase I and ester pro...Continue Reading

Citations

Jan 1, 1990·Histochemistry·R Gossrau, H Franz
Jan 1, 1985·Anatomy and Embryology·D BremerR Gossrau
Jan 1, 1981·Histochemistry·S Gutschmidt, R Gossrau
Jan 1, 1987·Histochemistry·R GossrauC Hanski
Jan 1, 1982·Histochemistry·K Jedrzejewski, P Kugler
Jan 1, 1980·Histochemistry·R Gossrau, Z Lojda
Jan 1, 1985·Histochemistry·P KuglerJ Scherberich
Jul 1, 1984·Felʹdsher i akusherka·E V Vinogradov, N F Kanaev
Oct 1, 1985·The Histochemical Journal·Z Lojda
May 1, 1983·The Histochemical Journal·Z Lojda, E Havránková
Apr 1, 1984·The Histochemical Journal·J Blanke, R Gossrau
Apr 1, 1984·The Histochemical Journal·R Gossrau, H J Merker
Apr 1, 1984·The Histochemical Journal·R Graf
May 1, 1985·The Histochemical Journal·R Gossrau
May 1, 1985·The Histochemical Journal·R GossrauR Graf
May 1, 1985·The Histochemical Journal·R Graf, R Gossrau
Jul 1, 1985·The Histochemical Journal·R Gossrau
Sep 1, 1989·The Histochemical Journal·M Ruhnke, R Gossrau
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T Pahlitzsch, P Sinha
Jan 1, 1991·Acta histochemica·D StillerC August
Jan 1, 1984·Acta histochemica·W Ovtscharoff, K Ichev

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