Abstract
The aim of this study was to investigate serotonin (5-HT) receptors in the penile bulb, which have been suggested to play a role in penile erection. Serotonin (10(-7)-3 x 10(-4) M) contracted penile bulbs in a concentration-dependent manner. Ketanserin (5-HT(2A) antagonist, 10(-9)-10(-7) M) and prazosin (alpha(1)-adrenergic receptor blocker, 10(-9)-10(-7) M) suppressed the lower and upper parts of concentration-response curves to 5-HT, respectively. Guanethidine (adrenergic neuron blocker, 5 x 10(-5) M) reduced the responses to 5-HT at only 10(-4) and 3 x 10(-4) M concentrations. NAN-190 (5-HT(1A) antagonist, 10(-8), 10(-7) M) shifted the concentration-response curve to the right with a reduction in the maximum response to 5-HT. While ondansetron (5-HT(3) antagonist, 10(-6)-10(-5) M) and GR55562 (5-HT(1B/1D) antagonist, 10(-6)-10(-5) M) had no effect on the concentration-response curve to 5-HT. The 5-HT(1A) agonist 8-OH-DPAT (10(-7)-3 x 10(-4) M) contracted penile bulbs in a concentration-dependent manner with a lower pD(2) value than that of 5-HT. Sumatriptan (5-HT(1B/1D) agonist, 10(-8)-10(-4) M) did not produce any contractile response in the penile bulbs. Prucalopride, a selective 5-HT(4) agonist (R093877, 10(-7)-3 x 10(-4)...Continue Reading
References
Dec 1, 1979·Molecular and Cellular Endocrinology·K H Jakobs
Oct 1, 1976·British Journal of Pharmacology·E ApperleyG P Levy
Dec 1, 1975·European Journal of Pharmacology·K StarkeT Endo
Jan 1, 1992·Pharmacology·I KrischR Rucman
Nov 26, 1991·European Journal of Pharmacology·K H Buchheit, T Buhl
Nov 1, 1990·British Journal of Pharmacology·J P Finberg, Y Vardi
Jun 1, 1990·Psychology and Aging·Gregory C Smith, Susan K Whitbourne
Jan 1, 1990·Psychopharmacology·H H BerendsenC L Broekkamp
Mar 31, 1987·European Journal of Pharmacology·H H Berendsen, C L Broekkamp
Nov 1, 1987·The Journal of Urology·M FovaeusH Hedlund
Dec 1, 1995·Acta Physiologica Scandinavica·P HedlundK E Andersson
Nov 5, 1997·European Journal of Pharmacology·C C Gerhardt, H van Heerikhuizen
Feb 6, 1999·Journal of Clinical Psychopharmacology·R C RosenM Menza
Aug 24, 1999·British Journal of Pharmacology·N H PrinsJ A Schuurkes
Sep 1, 1999·International Journal of Impotence Research·E S HayesS C Ng
Apr 15, 2000·The Journal of Physiology·H Hashitani
Dec 28, 2000·Life Sciences·A YonezawaY Kimura
Jul 5, 2001·European Journal of Pharmacology·M R BriejerJ A Schuurkes
Nov 7, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M R BriejerJ A Schuurkes
Jan 5, 2002·Lancet·N J Talley
Aug 2, 2002·International Journal of Impotence Research·E S Hayes, P G Adaikan
Apr 24, 2003·Urological Research·Kadir TürkölmezSümer Baltaci
May 28, 2003·Urological Research·Stefan UckertUdo Jonas
Aug 23, 2003·International Journal of Impotence Research·K FurukawaT Uchiyama
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G LeclereR A Lefebvre