Investigation of spectral performance for single-scan contrast-enhanced breast CT using photon-counting technology: A phantom study

Medical Physics
Veikko RuthWilli A Kalender

Abstract

Contrast-enhanced imaging of the breast is frequently used in breast MRI and has recently become more common in mammography. The purpose of this study was to make single-scan contrast-enhanced imaging feasible for photon-counting breast CT (pcBCT) and to assess the spectral performance of a pcBCT scanner by evaluating iodine maps and virtual non-contrast (VNC) images. We optimized the settings of a pcBCT to maximize the signal-to-noise ratio between iodinated contrast agent and breast tissue. Therefore, an electronic energy threshold dividing the x-ray spectrum used into two energy bins was swept from 23.17 keV to 50.65 keV. Validation measurements were performed by placing syringes with contrast agent (2.5 mg/ml to 40 mg/ml) in phantoms with 7.5 cm and 12 cm in diameter. Images were acquired at different tube currents and reconstructed with 300 μm isotropic voxel size. Iodine maps and VNC images were generated using image-based material decomposition. Iodine concentrations and CT values were measured for each syringe and compared to the known concentrations and reference CT values. Maximal signal-to-noise ratios were found at a threshold position of 32.59 keV. Accurate iodine quantification (average root mean square error of 0...Continue Reading

References

Mar 1, 1991·Medical Physics·D M TuckerD P Chakraborty
Dec 1, 1995·Clinical Radiology·F L FlanaganJ T Ennis
Aug 17, 2006·Physics in Medicine and Biology·P BaldelliM Gambaccini
Sep 6, 2006·Physics in Medicine and Biology·Yiannis KyriakouWilli A Kalender
Oct 21, 2006·Journal of Mammary Gland Biology and Neoplasia·John M BooneThomas R Nelson
Dec 8, 2006·European Radiology·Thorsten R C JohnsonChristoph R Becker
Jun 10, 2010·Medical Physics·Erik FredenbergMats Danielsson
Aug 20, 2010·Radiology·Nicolas D PrionasJohn M Boone
Sep 15, 2010·European Radiology·Clarisse DromainCorinne Balleyguier
Jun 2, 2011·Medical Physics·Shih-Ying HuangMartin J Yaffe
Nov 8, 2012·Journal of Medical Screening·Livia GiordanoE Suonio
Dec 11, 2013·Medical Physics·Robert E Alvarez
Jun 25, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christiane K KuhlHeribert B Bieling
Sep 27, 2014·Physics in Medicine and Biology·Thomas KoenigTilo Baumbach
Sep 12, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carol E DeSantisAhmedin Jemal
Jun 17, 2016·European Radiology·Willi A KalenderEvelyn Wenkel
Nov 9, 2016·European Radiology·Stefanie WeigelO Heidinger
Jul 28, 2017·The British Journal of Radiology·Christiane K Kuhl
Aug 8, 2017·IEEE Transactions on Medical Imaging·Andrey Makeev, Stephen J Glick
Sep 14, 2017·Medical Physics·Peter TruebChristian Broennimann
Apr 7, 2018·Magnetic Resonance Imaging Clinics of North America·John Lewin
Feb 28, 2019·The British Journal of Radiology·Shadi Aminololama-ShakeriKaren K Lindfors

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