Investigation of superharmonic sound propagation and imaging in biological tissues in vitro

The Journal of the Acoustical Society of America
Qingyu MaYong Ma

Abstract

This article presents both theoretical and experimental studies on the superharmonic generation and its imaging in biological tissues. A superharmonic component is defined as a summation of the third-, fourth-, and fifth-order harmonics. A superharmonic signal is produced using an 8-mm-diam, 2.5-MHz planar piston source that is excited by eight-cycle, 2.5-MHz tone bursts. Axial and lateral field distributions of the superharmonic component and the second harmonic are first calculated based on the nonlinear KZK model and then compared with those experimentally determined at two different source pressures of 0.5 and 1 MPa. Results indicate that the amplitude of the superharmonic component can exceed that of the second harmonic, depending on the axial distance and the fundamental pressure amplitude. Also, the 3-dB beamwidth of the superharmonic component is about 23% narrower than that of the second harmonic. Additional experiments are performed in vitro using liver and fatty tissues in transmission mode and produced two-dimensional images using the fundamental, the second harmonic, and the superharmonic signals. Although the clinical applicability of this work still needs to be assessed, these results indicate that the superharmo...Continue Reading

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Citations

Nov 18, 2011·The Journal of the Acoustical Society of America·Paul L M J van NeerNico de Jong
Nov 16, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Paul L M J van NeerNico de Jong
Nov 13, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Sevan HarputSteven Freear
Jun 23, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·François VarrayChristian Cachard
Feb 25, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Paul L M J van NeerNico de Jong
Jun 22, 2013·Physics in Medicine and Biology·M G DanilouchkineN de Jong
Oct 28, 2016·Journal of Medical Systems·Narendra D Londhe, Jasjit S Suri

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