Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions

International Journal of Pharmaceutics
Ljiljana DjekićDanica Agbaba

Abstract

The current study investigates the performances of the multicomponent mixtures of nonionic surfactants regarding the microemulsion stabilisation, drug solubilization and in vitro drug release kinetic. The primary surfactant was PEG-8 caprylic/capric glycerides (Labrasol). The cosurfactants were commercially available mixtures of octoxynol-12 and polysorbate 20 without or with the addition of PEG-40 hydrogenated castor oil (Solubilisant gamma 2421 and Solubilisant gamma 2429, respectively). The oil phase of microemulsions was isopropyl myristate. Phase behaviour study of the pseudo-ternary systems Labrasol/cosurfactant/oil/water at surfactant-to-cosurfactant weight ratios (K(m)) 40:60, 50:50 and 60:40, revealed a strong synergism in the investigated tensides mixtures for stabilisation of microemulsions containing up to 80% (w/w) of water phase at surfactant +cosurfactant-to-oil weight ratio (SCoS/O) 90:10. Solubilization of a model drug ibuprofen in concentration common for topical application (5%, w/w) was achieved at the water contents below 50% (w/w). Drug free and ibuprofen-loaded microemulsions M1-M6, containing 45% (w/w) of water phase, were prepared and characterized by polarized light microscopy, conductivity, pH, rheolo...Continue Reading

References

Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·M Trotta
Jul 7, 2000·Journal of Colloid and Interface Science·M GrassiL Magarotto
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M KreilgaardJ W Jaroszewski
Mar 16, 2001·International Journal of Pharmaceutics·M J Alvarez-Figueroa, J Blanco-Méndez
Sep 29, 2001·International Journal of Pharmaceutics·Y S RheeS C Chi
Jun 22, 2002·Journal of Drug Targeting·Sudarat EaimtrakarnKanji Takada
May 8, 2004·International Journal of Pharmaceutics·Ljiljana DjordjevicDanina Krajisnik
May 8, 2004·International Journal of Pharmaceutics·Y V Rama PrasadKanji Takada
Jun 28, 2005·International Journal of Pharmaceutics·Julia D R SchulzeAbdul W Basit
Apr 8, 2006·International Journal of Pharmaceutics·Huabing ChenXiangliang Yang
Jun 6, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kenjiro KogaKanji Takada
Aug 24, 2006·International Journal of Pharmaceutics·X ZhaoY Li
Nov 7, 2006·International Journal of Pharmaceutics·Shirzad AzarmiRaimar Löbenberg
Aug 19, 2007·Journal of Pharmaceutical Sciences·Sandra HeuschkelReinhard H H Neubert
Dec 20, 2007·Advanced Drug Delivery Reviews·Sagar S Rane, Bradley D Anderson
Nov 19, 2010·Postgraduate Medicine·H Richard Barthel, Robert A Axford-Gatley
Nov 30, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Reinhard H H Neubert

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Citations

Mar 19, 2014·Colloids and Surfaces. B, Biointerfaces·Rakesh Kumar, V R Sinha
Jan 21, 2016·Journal of Biomaterials Science. Polymer Edition·Rong ChenShaoyun Guo
Jul 8, 2015·Journal of Pharmaceutical Sciences·Carolina AloisioAnselmo Gomes De Oliveira
Feb 3, 2016·International Journal of Pharmaceutics·Abdelkader MouriJean-Marie Devoisselle
Dec 22, 2015·International Journal of Pharmaceutics·E GuéA Malzert-Fréon
Apr 5, 2016·Biological & Pharmaceutical Bulletin·Sureewan DuangjitTanasait Ngawhirunpat
Apr 5, 2014·Journal of Microencapsulation·Ahmet DogrulFigen Tirnaksiz
Mar 17, 2015·International Journal of Pharmaceutics·Maja Lusina KregarJelena Filipović-Grčić
May 1, 2016·International Journal of Pharmaceutics·Airlla L M CavalcantiBolívar P G L Damasceno
May 10, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ljiljana DjekicMarija Primorac
Jul 5, 2016·International Journal of Molecular Sciences·Letícia StreckArnóbio Antônio da Silva-Júnior
Oct 7, 2017·Sports Medicine - Open·Martin Anthony Christopher ManoukianCharles DeMesa
Apr 11, 2020·Pharmaceutics·Kyeong-A RyuSung Tae Kim
Oct 10, 2020·Assay and Drug Development Technologies·Madhur KulkarniAditya Marfatiya

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