Investigation of suspected Guillain-Barre syndrome in childhood: what is the role for gadolinium enhanced magnetic resonance imaging of the spine?

Journal of Paediatrics and Child Health
Nicholas SmithPadraic Grattan-Smith

Abstract

To review the role of gadolinium-enhanced magnetic resonance imaging of the spine in the diagnosis of paediatric Guillain-Barre syndrome and compare it with nerve conduction studies and cerebrospinal fluid analysis. A retrospective review of investigations undertaken in children admitted to our institution with acute Guillain-Barre syndrome over a 10-year period was performed. Seven of eight children (88%) displayed post-gadolinium nerve root enhancement consistent with Guillain-Barre syndrome. This compared with supportive nerve conduction studies in 21/24 children (88%) and cerebrospinal fluid protein analysis consistent with the diagnosis in 16/20 children (80%). Nerve conduction studies are the recognised 'gold standard' technique for confirming a clinical diagnosis of Guillain-Barre syndrome. In this study, a high positive rate was demonstrated. While more experience is necessary, this study and the literature support gadolinium enhanced magnetic resonance imaging of the spine as a valuable, although not necessarily superior, investigation in the diagnosis of Guillain-Barre syndrome. It may be of particular benefit when specialist neurophysiology expertise is unavailable.

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Citations

Aug 17, 2011·Journal of Paediatrics and Child Health·Hong-Liang ZhangJiang Wu
Dec 17, 2011·Journal of Paediatrics and Child Health·Nicholas Jc SmithPadraic Grattan-Smith
Mar 3, 2017·Journal of Neurology·Joyce RoodbolBart C Jacobs
Jul 19, 2012·Muscle & Nerve·Vânia AlmeidaLuca Padua
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Simon Rinaldi

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