Investigation of the antifungal activity of caledonixanthone E and other xanthones against Aspergillus fumigatus

Planta medica
G LarcherJean-Philippe Bouchara

Abstract

Among the different xanthones previously isolated from the stem bark of Calophyllum caledonicum, caledonixanthone E presented the strongest activity (MIC (80) = 8 microg/mL) in acidic conditions (pH 3) against the human pathogenic fungus Aspergillus fumigatus. Phase-contrast microscopy studies suggested the assembly or synthesis of cell wall components as the target of the drug. Moreover, the use of fluorescent lectins further supported an impact of caledonixanthone E on the synthesis of chitin, the major structural polysaccharide of the fungal wall. These results suggest that caledonixanthone E may be an interesting model for the design of new antifungal drugs.

Citations

Feb 26, 2010·Journal of Asian Natural Products Research·Tasleem ArifRajesh Dabur
Jul 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Freddy A Bernal, Ericsson Coy-Barrera
Jan 18, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Benoit PinelPascal Richomme
Jan 22, 2013·Journal of Pharmaceutical and Biomedical Analysis·Anna Lisa PiccinelliLuca Rastrelli
Jun 17, 2008·Journal of Natural Products·Adonis Bello AlarcónLuca Rastrelli

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