Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization

Journal of Pharmaceutical Sciences
Teresa JongIan Larson

Abstract

This study aimed to investigate the surface energy factors behind improved aerosolization performance of spray-dried colistin powder formulations compared with those produced by jet milling. Inhalable colistin powder formulations were produced by jet milling or spray drying (with or without l-leucine). Scanning electron micrographs showed the jet-milled particles had irregularly angular shapes, whereas the spray-dried particles were more spherical. Significantly higher fine particle fractions were measured for the spray-dried (43.8%-49.6%) versus the jet-milled formulation (28.4%) from a Rotahaler at 60 L/min; albeit the size distribution of the jet-milled powder was smaller. Surprisingly, addition of l-leucine in the spray drying feed solution gave no significant improvement in fine particle fraction. As measured by inverse gas chromatography, spray-dried formulations had significantly (p < 0.001) lower dispersive, specific, and total surface energy values and more uniform surface energy distributions than the jet-milled powder. Interestingly, no significant difference was measured in the specific and total surface energy values between the spray-dried formulation with or without l-leucine. Based on our previous findings in th...Continue Reading

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Citations

Feb 24, 2018·Future Medicinal Chemistry·Arcadia Woods, Khondaker Miraz Rahman
Dec 10, 2019·Expert Opinion on Drug Delivery·Nivedita ShettyQi Tony Zhou
Jun 21, 2020·Pharmaceutics·Frédéric TewesSandrine Marchand
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Aug 11, 2021·Pharmaceutics·Hisham Al-ObaidiSefinat Opesanwo

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