Investigation of the determinants of nuclear pore number

Cytogenetics and Cell Genetics
G G MaulW Beçak

Abstract

To assess the functional significance of nuclear pore complexes, we have investigated whether the number of pores per nucleus is determined by such factors as the nuclear volume, nuclear surface area, DNA content, or aspects of nuclear activity. Comparisons were made between cell types chosen to permit observation of differences in nuclear pore number as a function of differences in the other qualities measured. The number of nuclear pores was determined by freeze-etching and measurements of nuclear surface and nuclear volume by electron and light microscopy. Pairs of cell strains in culture that contained different numbers of chromosome sets were investigated to examine the relation of pore number to total DNA content. Tetraploid cells of the rat kangaroo (Potorous tridactylus) have almost exactly twice the number of pores found in the parental diploid strain. However, the pore number in diploid grassfrog (Rana pipiens) cells was only 65% greater than in the parental haploid cells. In addition, a polyploid series of nucleated RBC had a 62% pore number increase with each successive increase in ploidy. Diploid cell strains from the canyon mouse (Peromyscus crinitus) and from the cactus mouse (P. eremicus) were compared to test w...Continue Reading

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