Investigation of the differences between the "Cold" and "Hot" nature of Coptis chinensis Franch and its processed materials based on animal's temperature tropism

Science in China. Series C, Life Sciences
CanPing ZhouXiaoHe Xiao

Abstract

The description and differentiation of the so-called "Cold" and "Hot" natures, the primary "Drug Naure" of Chinese medicine, is the focus of theoretical research. In this study, the divergency between the "Cold" and the "Hot" natures was investigated through examining the temperature tropism of mice affected by Coptis chinensis Franch and its processed materials by using a cold/hot plate differentiating technology. After exposure to C. chinensis Franch, the macroscopic behavioral index of the remaining rate (RR) on a warm pad (40 degrees C) significantly increased (P<0.05), suggesting the enhancement of Hot tropism. The internal indexes of adenosine triphosphatase (ATPase) activity and oxygen consuming volume decreased significantly (P<0.05), suggesting the decapability of energy metabolism. This external behavior of Hot tropism might reflect the internal Cold nature of C. chinensis Franch. However, the processed materials of C. chinensis Franch exhibited a different Cold nature in temperature tropism compared with crude C. chinensis Franch (CC): the Cold nature of bile-processed C. chinensis Franch (BC) enhanced while the ginger-processed C. chinensis Franch (GC) changed inversely. The changing sequence was consistent with the...Continue Reading

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Citations

Jun 25, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Jingxiang PangJinxiang Han
Sep 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hongbo YangLei Jia
Dec 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jia-Min YangYu-Hang Li
Apr 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Shi SunXinguang Liu
Feb 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xianjun FuZhenguo Wang
Mar 4, 2017·Journal of Chemical Information and Modeling·Xianjun FuAndreas Bender

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