Investigation of the drug release and surface morphological properties of film-coated pellets, and physical, thermal and mechanical properties of free films as a function of various curing conditions.

AAPS PharmSciTech
Sushmita Bhattacharjya, Dale Eric Wurster

Abstract

The purpose of the present investigation was to elucidate the influence of curing on different physical properties of Eudragit NE and RS coating systems. Increased curing times resulted in decreased drug release rates from Eudragit NE-coated beads. However, an increase in drug release rates was noticed at longer curing times and higher temperatures for the Eudragit RS coating system. The surface morphological changes of the film-coated beads revealed that there were no visible macroscopic changes as a result of curing. The absence of any ibuprofen melting peak in the DSC thermograms of cured NE and RS coated beads confirmed that there was no surface crystallization of ibuprofen. These results indicated that the increase in drug release rates from RS coated pellets, when subjected to long curing times, resulted from loss of plasticizer. Free films of Eudragit NE exhibited an increase in tensile strength with increased curing times, whereas Eudragit RS free films showed a decrease in tensile strength beyond 4 h of curing at 70 and 90 degrees C. The film thicknesses and weights of free films of Eudragit RS prepared with triethyl citrate plasticizer were found to change more dramatically with curing than did free films of Eudragit ...Continue Reading

References

Oct 6, 2007·AAPS PharmSciTech·Dale Eric WursterDouglas R Flanagan

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Citations

Jan 24, 2013·Expert Opinion on Drug Delivery·Linda A Felton, Stuart C Porter
Jan 12, 2013·International Journal of Pharmaceutics·Linda A Felton
Dec 15, 2015·International Journal of Pharmaceutics·Samuel K Owusu-WareMilan D Antonijević
Jan 26, 2017·Pharmaceutical Development and Technology·Venkata Ramana NaiduPravin S Wakte
Sep 12, 2020·Pharmaceutics·Ki-Soo SeoHyo-Kyung Han
Apr 16, 2017·AAPS PharmSciTech·Suélen Plaza PominOsvaldo Albuquerque Cavalcanti
Jul 7, 2018·AAPS PharmSciTech·Yingjian Li, Dale Eric Wurster

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