PMID: 8995651Feb 1, 1997Paper

Investigation of the dynamics of the spread of human immunodeficiency virus to brain and other tissues by evolutionary analysis of sequences from the p17gag and env genes

Journal of Virology
E S HughesP Simmonds

Abstract

The time of spread of human immunodeficiency virus type 1 (HIV-1) from lymphoid to nonlymphoid tissues in the course of infection was investigated by sequence comparisons of variants infecting a range of lymphoid and nonlymphoid tissues from three individuals with AIDS in the pl7gag gene and regions flanking the V1/V2 hypervariable regions. Phylogenetic analysis in both regions revealed several lineages in each individual that contained sequences from both lymphoid and nonlymphoid tissues such as the brain. This observation contrasts strongly with the previously described organ-specific sequences in the V3 region in this study population and other investigations. Although individual pairwise comparisons of relatively short sequences such as p17gag are subject to considerable stochastic error, we found that the diversity of gag sequences in variants from lymphoid tissue was consistently lower than that found among variants amplified from the brain. By estimating mean synonymous pairwise distances in the p17gag region, we were able to make an approximate calculation of the ages of populations in different tissues. Those from lymphoid tissue ranged from 2.65 to 5.6 years in the three study subjects, compared with 4.1 to 6.2 years ...Continue Reading

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Citations

Nov 17, 1999·Neuropathology and Applied Neurobiology·G S TomlinsonJ E Bell
Feb 13, 2002·AIDS Research and Human Retroviruses·Katia AlvesE L Delwart
Apr 15, 1999·Annual Review of Neuroscience·F González-Scarano, G Baltuch
Dec 1, 2005·Brain : a Journal of Neurology·M McCrossanP Simmonds
Dec 16, 2005·Cell Research·J Roberto TrujilloRobert C Gallo
Mar 14, 2007·Evolution; International Journal of Organic Evolution·Antonio V BorderíaRafael Sanjuán
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeanne E BellPeter Simmonds
Feb 23, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C PowerR T Johnson
Jun 8, 2002·Annual Review of Neuroscience·Kenneth C Williams, William F Hickey
Jul 23, 2004·Evolution; International Journal of Organic Evolution·Rafael SanjuánSantiago F Elena
Aug 21, 2010·Immunologic Research·K Grovit-Ferbas, M E Harris-White
Dec 1, 2004·Histopathology·J E Bell
Jun 1, 2006·Brain : a Journal of Neurology·Satish K PillaiJoseph K Wong
Oct 9, 2014·Der Nervenarzt·C Eggers, UNKNOWN für die Deutsche Neuro-AIDS-Arbeitsgemeinschaft (DNAA)
Jan 7, 1998·Journal of Virology·E L DelwartM K Singh
Jun 2, 2017·Journal of Neurology·Christian EggersUNKNOWN German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)

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