Investigation of the effective components of the flowers of Trollius chinensis from the perspectives of intestinal bacterial transformation and intestinal absorption

Pharmaceutical Biology
Lina GuoRufeng Wang

Abstract

The flowers of Trollius chinensis Bunge (Ranunculaceae), used for respiratory tract infections, mainly contain flavonoids, phenolic acids, and alkaloids; however, the effective components are debatable because of their unclear in vivo activities. This study investigates the effective components from the perspectives of biotransformation and absorption. Both single person derived- and multiple people-derived intestinal florae were used to investigate the biotransformation of aqueous extract of the flowers of T. chinensis (AEOF) at the concentrations of 15.0, 30.0, and 60.0 mg/mL, respectively, for 72 h. Both human colon adenocarcinoma cell line (Caco-2) monolayers and everted gut sacs were employed to evaluate the intestinal absorption of the intestinal bacterial transformed AEOF at the concentrations of 10, 20, and 30 mg/mL, respectively, for 180 min. 2″-O-β-l-Galactopyranosylorientin, orientin, vitexin, quercetin, veratric acid, proglobeflowery acid, and trolline in AEOF were not transformed by intestinal bacteria, while isoquercetin and trollioside were completely transformed. The Papp values of 2″-O-β-l-galactopyranosylorientin, orientin, and vitexin calculated based on the experimental data of intestinal absorption were at ...Continue Reading

References

Mar 11, 2004·Journal of Asian Natural Products Research·Ru-Feng WangJong-Hee Park
Dec 29, 2006·Chemistry & Biodiversity·Shao-Qing CaiYukihiro Shoyama
Apr 26, 2013·Journal of Asian Natural Products Research·Ru-Feng WangXiu-Wei Yang
Nov 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiu-Wen WuCan Zhao
Aug 12, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yanhua QinXi Li
Sep 4, 2015·Journal of Agricultural and Food Chemistry·Long DingJingbo Liu
Mar 31, 2016·Chinese Journal of Natural Medicines·Ming YuanYi Ding

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BETA
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