Investigation of the effects of enteral hormones on the pyloric muscle in newborn rats

Journal of Pediatric Surgery
Özlem BoybeyiMustafa Kemal Aslan

Abstract

To investigate the effects of enteral hormones on pyloric muscle in order to clarify the etiopathogenesis of hypertrophic pyloric stenosis (HPS). Forty-two newborn Wistar-Albino rats were included. No intervention was done in the control group (CG, n=6). In the sham group (SG, n=6) 1ml saline (0.9% NaCl solution), in the Nw-nitro-l-arginine methyl ester hydrochloride (L-NAME) group (LNG, n=6) 100mg/kg/d L-NAME, in the somatostatin group (STG, n=6) 7mcg/kg/d ST, in the cholecystokinin group (CCKG, n=6) 3mcg/kg/d CCK, in the substance P group (SPG, n=6) 5ml/kg/d SP, and in the prostaglandin-E1 group (PGE1G, n=6) a cumulative dose of 360mcg/kg PGE1 was given intraperitoneally for 14days. On the 21st day, histopathological examination and muscle thickness measurements were done. Results were evaluated statistically. Total and circular pyloric muscle thicknesses were significantly increased in the LNG compared to the CG and SG (p<0.05). Circular pyloric muscle thickness was not increased in the STG, CCKG and SPG compared to the CG and SG (p>0.05). In the PGE1G, muscle thickness was significantly decreased in the pylorus and increased in the antrum compared to the CG and SG (p<0.05). Nitric oxide synthase (NOS) inhibition with L-NAME...Continue Reading

References

Aug 20, 1992·The New England Journal of Medicine·N PeledG Koren
Jul 5, 2007·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·W KosiakM Chojnicki
Oct 31, 2007·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·M LacherD V Schweinitz
Sep 18, 2009·Pediatric Surgery International·Christina Panteli

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Citations

Aug 16, 2016·Seminars in Pediatric Surgery·Matthew Jobson, Nigel J Hall
Nov 18, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mehmet SarıkayaMetin Gündüz

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