PMID: 9528161Apr 7, 1998Paper

Investigation of the effects of puff times and spacer devices on the distribution pattern of a Becotide 100 inhaler in the twin impinger

Arerugī = [Allergy]
F OjimaY Nakagawa

Abstract

In order to investigate the dispersion pattern and compare the effect of spacer devices (Volumatic, Volumatic Soft and InspirEase), the Becotide 100 inhaler actuating 100 micrograms of beclomethasone dipropionate (BDP) per shot was studied with respect to its distribution ratio in a twin impinger and also compared with that of the Becotide 50 inhaler. The distribution patterns of BDP during each stage of the twin impinger were not affected by the puff times of the Becotide 100 inhaler. No significant difference was observed when the distribution ratios between the Becotide 50 inhaler and Becotide 100 inhaler were compared. All of these three spacer devices reduced the deposition ratio in stage I which is assumed to be the oral cavity and oropharynx. As the puff times of the Becotide 100 inhaler increased, the BDP deposited in the spacer increased and that of stage II assumed to be the lung decreased. These results suggested that the inhalation volume of BDP would depend on the puff times during clinical use and the inhalation volume of BDP for the Becotide 100 inhaler would be double that of the Becotide 50 inhaler. The spacer devices could decrease the local adverse effects caused by deposited BDP in the oral cavity. When usin...Continue Reading

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