PMID: 11337158May 5, 2001Paper

Investigation of the felodipine glassy state by atomic force microscopy

International Journal of Pharmaceutics
A TrojakStane Srčič

Abstract

The glassy state of felodipine was prepared by melting crystals of felodipine on a clean glass slide and cooling to room temperature. It has been confirmed that glassy felodipine is a metastable state, and undergoes transformation to the more stable crystalline form. Crystallization occurred slowly and spontaneously at room temperature, below the glassy state transition temperature (Tg). The contact mode of atomic force microscopy was used for topographical imaging of the glassy and crystalline states of felodipine. When the glassy felodipine region next to the recrystallized zone was exposed to controlled mechanical stress through the tip, rapid additional crystallization was observed. This crystallization process can be induced and imaged in real time by atomic force microscopy.

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Citations

Mar 8, 2003·International Journal of Pharmaceutics·Paulus SeitavuopioJouko Yliruusi
May 6, 2009·AAPS PharmSciTech·Pradeep R PatilAnant R Paradkar
Jul 23, 2013·International Journal of Pharmaceutics·B JankovićO Planinšek
Jun 2, 2011·International Journal of Pharmaceutics·Jianxin ZhangClive J Roberts
Jan 18, 2007·The Journal of Pharmacy and Pharmacology·Sheere BangaArvind K Bansal
Jan 31, 2017·The Journal of Pharmacy and Pharmacology·Renu ChadhaJamshed Haneef

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