Investigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Birgit MertensLuc Verschaeve

Abstract

Due to the worldwide concern that bisphenol A might act as an endocrine disruptor, alternative materials for polycarbonate (PC) have been introduced on the European market. However, PC-replacement products might also release substances of which the toxicological profile--including their genotoxic effects--has not yet been characterized. Because a thorough characterization of the genotoxic profile of all these substances is impossible in the short term, a strategy was developed in order to prioritize those substances for which additional data are urgently needed. The strategy consisted of a decision tree using hazard information related to genotoxicity. The relevant information was obtained from the database of the European Chemicals Agency (ECHA), in silico prediction tools (ToxTree and Derek Nexus(TM)) and the in vitro Vitotox(®) test for detecting DNA damage. By applying the decision tree, substances could be classified into different groups, each characterized by a different probability to induce genotoxic effects. Although none of the investigated substances could be unequivocally identified as genotoxic, the presence of genotoxic effects could neither be excluded for any of them. Consequently, all substances require more d...Continue Reading

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Citations

Apr 5, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Matthias OnghenaAdrian Covaci
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Birgit MertensJoris Van Loco
Oct 19, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Coraline SimonMarc Elskens
Oct 28, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Emilie SoutonChagnon Marie-Christine
Feb 10, 2017·Archives of Toxicology·Melissa Van BossuytBirgit Mertens
Mar 4, 2020·Environmental Health : a Global Access Science Source·Jane MunckeMartin Scheringer
Nov 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sophia BarhdadiTamara Vanhaecke
Dec 5, 2020·Environment International·Ksenia J GrohJane Muncke

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