Investigation of the glidant properties of compacted colloidal silicon dioxide by angle of repose and X-ray photoelectron spectroscopy

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
S JonatP C Schmidt

Abstract

The optimal flow-enhancing effect of a new compacted, hydrophilic colloidal silicon dioxide (AEROSIL 200 VV Pharma) on microcrystalline cellulose (Avicel PH 101) and pregelatinized starch (Starch 1500) was found to be 0.25% under gentle and 0.125% under strong mixing conditions, as measured by the angle of repose. The effect could be explained by X-ray photoelectron spectroscopy (XPS) investigations. The Si 2p signals of the silicon dioxide indicated that the coverage of the excipient surface with AEROSIL was greater for all mixtures produced under strong mixing conditions and corresponded to a higher degree of de-agglomeration of the AEROSIL aggregates. The more extensive surface coverage of Avicel PH 101 as compared to Starch 1500 could be explained by the particle morphology on the one hand and by the XPS C 1s signals on the other. Due to the different conformation of the two excipients, Avicel PH 101 offers a higher density of hydroxyl groups on its surface which are available for hydrogen bonding with the surface hydroxyl groups of hydrophilic colloidal silicon dioxide.

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Citations

Sep 15, 2010·Indian Journal of Pharmaceutical Sciences·T PhaechamudS Chitrattha
Apr 5, 2011·Drug Development and Industrial Pharmacy·Orsolya Jójárt-Laczkovich, Piroska Szabó-Révész
Mar 15, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sharad MangalIan Larson
May 11, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diana MajerováPetr Zámostný
Jul 3, 2009·Chemical & Pharmaceutical Bulletin·Hidaka AbeHirofumi Takeuchi
Jun 11, 2020·Pharmaceutics·Karnkamol TrisoponOrnanong Suwannapakul Kittipongpatana
Nov 12, 2021·Drug Development and Industrial Pharmacy·Paulo J SalústioPaulo J Costa

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