Investigation of the hair of patients with scalp psoriasis using atomic force microscopy

Clinical and Experimental Dermatology
M K ShinC R Haw

Abstract

Psoriasis affects not only the soft keratin of the skin, but also hard keratin, such as nails and hair. However, few studies have described the changes induced in the hair of patients with psoriasis. Using atomic force microscopy (AFM), we investigated the morphological property of hair samples taken from the scalp of patients with psoriasis. Lesional and nonlesional hairs taken from 15 patients with scalp psoriasis were investigated. Hairs from 15 healthy adults were also examined as controls. Using AFM, surface images were taken of an area of 20 × 20 μm(2), with 512 × 512 pixels and a scan speed of 0.8 lines/s. results: Pits were frequently seen in the hair shafts of patients with psoriasis, similar to those seen in their nail plates. Macropit number, scale thickness and surface roughness were all significantly increased in lesional hairs compared with both nonlesional and control hairs, and macropits and scale thickness were also increased in nonlesional hairs compared with control hairs. The hair shafts of patients with scalp psoriasis exhibited the same macropits seen in their nails. Both lesional and nonlesional hairs had similar changes in morphological structure compared with controls. This supports the generalized natu...Continue Reading

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Citations

Jun 26, 2012·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Kyung Sook Kim, Hun-Kuk Park
Aug 29, 2012·Journal of Biomedicine & Biotechnology·Trinh Hermanns-LêClaudine Piérard-Franchimont
May 2, 2021·International Journal of Cosmetic Science·Antonella Tosti, James R Schwartz
Sep 30, 2021·Experimental Dermatology·Takahiro SuzukiRalf Paus

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