Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950

British Journal of Pharmacology
I K Anderson, G M Drew

Abstract

1. The effect of systemic administration of the nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) on the antihypertensive effects of the angiotensin AT1 receptor antagonist, GR138950, the angiotensin-converting enzyme (ACE) inhibitor, enalapril, or hydralazine has been evaluated in unrestrained, conscious renal artery ligated hypertensive (RALH) rats. The effect of the phosphodiesterase type V inhibitor, zaprinast on the antihypertensive effect of GR138950 in RALH rats was also examined. The effect of GR138950 on blood pressure, and plasma and urine cyclic GMP levels was compared to that of zaprinast in conscious RALH rats. 2. GR138950, enalapril or hydralazine caused marked reductions in blood pressure associated with immediate tachycardia in conscious RALH rats. L-NAME pretreatment attenuated the antihypertensive effects of GR138950 or enalapril but not that of hydralazine in conscious RALH rats. The initial tachycardia caused by GR138950 or enalapril but not hydralazine was attenuated by L-NAME pretreatment. L-NAME alone caused a transient (20 min) pressor response and a prolonged (6 h) bradycardia in conscious RALH rats. 3. Pretreatment with indomethacin did not affect the cardiovascular effect of...Continue Reading

References

Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Mar 1, 1991·American Journal of Hypertension·N JaiswalC M Ferrario
May 1, 1990·Hypertension·S M GardinerS Moncada
Jul 4, 1995·European Journal of Pharmacology·K L ClarkG M Drew
Jul 30, 1993·Biochemical and Biophysical Research Communications·T MalinskiD Bohr
Jan 1, 1994·British Journal of Pharmacology·A HilditchM J Robertson
Nov 16, 1993·European Journal of Pharmacology·R L DundoreE D Pagani
May 1, 1993·Current Problems in Diagnostic Radiology·A M DelBalso, R E Hall

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Citations

Sep 6, 2003·Advances in Therapy·Mohamed A IbrahimShiro Ueda
Feb 9, 2000·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Apr 13, 1999·The American Journal of Physiology·R A Cohen

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