Investigation of the interaction of amyloid β peptide (11-42) oligomers with a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane using molecular dynamics simulation

Physical Chemistry Chemical Physics : PCCP
Ning XiangGanesan Narsimhan

Abstract

Some amyloid related proteins/peptides are involved in aggregation and pore formation in phospholipid membranes (cell membranes), which result in a variety of neurological disorders such as Alzheimer's disease, Parkinson's disease and Huntington disease. In this research, the mechanism of pore formation by β amyloid (Aβ) peptides was investigated using molecular dynamics simulation by simulating the interaction of the Aβ(11-42) peptide, with a lipid membrane and the potential of the mean force of interaction was evaluated. A 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane system with different cholesterol concentrations was used to simulate the neural cell membrane. The results indicated that Aβ(11-42) peptide oligomers with peptide numbers larger than two were more likely to lead to lipid deformation and water channels, and the free energy of penetration into the membrane decreased with the increasing number of peptides. Increasing the concentration of cholesterol leads to a higher energy barrier for the penetration of peptide into the lipid bilayer thereby protecting the membrane. The results of this research have potential application in the prevention of pore formation by Aβ aggregates on the lipid membrane.

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Citations

Oct 10, 2019·Physical Chemistry Chemical Physics : PCCP·Abhilash Sahoo, Silvina Matysiak
Sep 24, 2019·Journal of Biomolecular Structure & Dynamics·Gianvito GrassoMarco A Deriu
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan LyuChioma M Okeoma
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pathomwat WongrattanakamonWipawadee Yooin

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Methods Mentioned

BETA
nuclear magnetic resonance
AFM
NMR

Software Mentioned

Visual Molecular Dynamics ( VMD )
CHARMM36
Gromacs
CHARMM
DSSP
- GUI

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