Investigation of the mechanism and the effect of cryoimmunology in the Copenhagen rat

Cryobiology
N E HoffmannJ C Bischof

Abstract

This study examined the potential for "cryoimmunology" to increase the destruction of the Dunning AT-1 prostate tumor after cryosurgery. Two possible mechanisms explaining the cryoimmunologic response were studied. The first was that an antitumor antibody is produced after cryosurgery. The second was that freezing induces an immunostimulatory signal that creates a T-cell response to the tumor. Six groups of animals (three experimental groups and three control groups) were treated once per week for 4 weeks with different therapies designed to investigate these mechanisms. Three types of immune response were measured: (1) the anti-AT-1 tumor immune titer (Ab response) by serum ELISA, (2) the effect on secondary tumor growth after challenge with live AT-1 cells (size and weight of the secondary tumor over time), and (3) the nature of the immunologic infiltrate into the secondary tumors by immunoperoxidase stain. ELISA showed that immune titers were present in the experimental groups after therapy, but the presence of an immune titer did not have a significant effect on tumor propagation. Histology showed the immunologic infiltrate was similar in all groups. These results showed that an immune response to AT-1 tumor was measurable ...Continue Reading

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Citations

Jul 31, 2009·Journal of Biomechanical Engineering·Raghav GoelJohn C Bischof
Dec 18, 2013·Immunotherapy·Abhinav Sidana
May 12, 2006·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Tom Mala
Oct 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Christopher BastianpillaiManit Arya
Sep 18, 2009·Urology·Abhinav SidanaRonald Rodriguez
Apr 2, 2008·Medical Engineering & Physics·Te-Hsuen ChenYi-You Huang
Jul 25, 2006·Hematology/oncology Clinics of North America·Robert L GrubbAdam S Kibel
Oct 17, 2009·Cryobiology·A A GageJ G Baust
Feb 19, 2004·Cryobiology·M O MaiwandJ E Beeson
Apr 3, 2004·Technology in Cancer Research & Treatment·Bumsoo HanJohn C Bischof
Apr 3, 2004·Technology in Cancer Research & Treatment·J G Baust, A A Gage
May 27, 2004·Technology in Cancer Research & Treatment·Robert J GriffinJohn C Bischof
Jun 25, 2003·Expert Review of Anticancer Therapy·Carlos E Bermejo, Louis L Pisters
Nov 15, 2017·The Kaohsiung Journal of Medical Sciences·Ming-Xiong ShengShu-Shang Chen
Mar 17, 2005·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
Nov 2, 2005·The Cancer Journal·Bulent AkdumanE David Crawford
Aug 3, 2005·Annals of Biomedical Engineering·Bumsoo HanJohn C Bischof
May 5, 2004·Annals of Surgical Oncology·Michael S SabelMichael Schultz
Dec 7, 2013·Expert Review of Medical Devices·Ayaz Aghayev, Servet Tatli
Jan 25, 2018·AJR. American Journal of Roentgenology·Stacy K Y FanMehran Midia
Jan 14, 2020·Annals of Plastic Surgery·Nader Elmelegy, Sameh Elghamry
Sep 21, 2001·Journal of Biomechanical Engineering·N E Hoffmann, J C Bischof

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