Investigation of the mode of inheritance of the HLA associated diseases by the method of antigen genotype frequencies among diseased individuals

Tissue Antigens
G Thomson

Abstract

Statistical features of the method of antigen genotype frequencies among the diseased, for single and multiple disease associations at a locus, will be presented. A methodology to determine when a true intermediate mode of inheritance can be distinguished from strict recessive or additive inheritance will be developed. The effect of sporadics and ascertainment bias on the observed antigen genotype frequencies will be investigated. Data on ankylosing spondylitis, multiple sclerosis and dermatitis herpetiformis are very close to expectations for an additive (or dominant) mode of inheritance for the HLA-linked disease-predisposing gene, and data on hemochromatosis, insulin dependent diabetes mellitus and celiac disease are close to recessive expectations. If an intermediate model does apply in any of these cases, it must be an intermediate model that is fairly close to a strict recessive or dominant model; as appropriate. DR data for insulin dependent diabetes mellitus (IDDM) strongly indicate that there are two separate "disease" alleles, which exhibit negative complementation, predisposing individuals to IDDM, where the mode of inheritance of the "disease" alleles considered separately is close to recessive. In general, this met...Continue Reading

References

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Citations

Jul 1, 1988·Annals of Human Genetics·F Clerget-DarpouxJ Hors
Jan 1, 1986·Genetic Epidemiology. Supplement·H PayamiG Thomson
Jan 1, 1986·Genetic Epidemiology. Supplement·S L Sherman
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·G Thomson
Dec 1, 1995·Journal of Epidemiology and Community Health·R WilliamsH Ford
Nov 1, 1996·Annals of Human Genetics·J R Green, S Shah
Dec 7, 2000·Genetic Epidemiology·S Tézenas du MontcelF Clerget-Darpoux
Aug 14, 2003·Genetic Epidemiology·A-S JannotF Clerget-Darpoux
Feb 1, 1986·Tissue Antigens·H PayamiC Dostal
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Jan 1, 1987·Annals of Human Genetics·E J LouisG Thomson
May 1, 1995·Tissue Antigens·M MutoC Asagami
Jan 1, 1986·Genetic Epidemiology. Supplement·E J LouisG Thomson
Sep 1, 1989·Arthritis and Rheumatism·W P RobinsonG Thomson
Jan 1, 1989·Genetic Epidemiology·F Clerget-Darpoux, M C Babron
Jan 1, 1989·Genetic Epidemiology·R S SpielmanF Clerget-Darpoux
Oct 1, 1985·Annals of Human Genetics·H PayamiE Hudes
Jan 1, 1986·Genetic Epidemiology. Supplement·J I RotterN K Maclaren
Nov 1, 1985·Tissue Antigens·G ThomsonE Hudes
Jan 1, 1993·Genetic Epidemiology·A S RigbyA J Silman
Jan 1, 1986·Genetic Epidemiology. Supplement·G ThomsonM Neugebauer
Apr 1, 1985·Tissue Antigens·A GovaertsJ Dausset
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Sep 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Theresa A AlyGeorge S Eisenbarth
Jan 1, 1995·Genetic Epidemiology·H BickeböllerF Clerget-Darpoux
Jul 22, 1998·Genetic Epidemiology·E GéninF Clerget-Darpoux
May 23, 2009·Biometrics·Jon Wakefield
Jan 1, 1989·Genetic Epidemiology·H PayamiG Thomson
Jan 1, 1994·Genetic Epidemiology·G Thomson, U Motro
Dec 1, 1995·Trends in Genetics : TIG·I P Tomlinson, W F Bodmer
Jun 1, 1991·Baillière's Clinical Endocrinology and Metabolism·G Thomson
Jun 2, 1998·Kidney International·F Clerget-Darpoux

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