Investigation of the molecular mechanisms of hepatic injury upon naphthalene exposure in zebrafish (Danio rerio)

Ecotoxicology
Hongshan ChenHongfeng Bian

Abstract

Naphthalene has been used worldwide as a commercial insecticide for decades, which when detected in the environment can have various negative effects on non-target organism, such as hepatotoxicity. However, the molecular mechanisms of how naphthalene acts to affect the liver in zebrafish (Danio rerio) remains unknown. In this study, we evaluated the potential toxic effects of naphthalene on livers in female adult zebrafish over a 21-day subacute exposure. Global hepatic gene expression was examined by microarrays and the results indicated the regulated genes were associated significantly with vital hepatic injury pathways and GO categories upon naphthalene exposure, such as disruptions in lipid metabolism, inflammatory response, and the carcinogenic processes. According to our observations of liver histology, nuclear enlargement as a potential indicator of cancers and hepatic lipometabolic disorder precisely were supported. The 96 h acute naphthalene tests on Tg(lysC:DsRed) and LiPan lines larvae revealed recruitment of neutrophils by the liver, as well as decreased liver size, which further confirmed hepatic inflammation response to naphthalene exposure. Thus, these findings advance the field of ecotoxicology by unveiling a ne...Continue Reading

References

Aug 24, 1999·Cell·J F BrombergJ E Darnell
Mar 13, 2003·Current Gastroenterology Reports·James H Grendell
Mar 21, 2003·Developmental Biology·Holly A FieldDidier Y R Stainier
Aug 12, 2003·Journal of Molecular Biology·Christine Schubert WrightFraydoon Rastinejad
Aug 20, 2003·Biostatistics·C M KendziorskiA D Attie
Sep 23, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Susan A Boackle
Feb 7, 2004·Biotechnology Progress·Kwanchanok ViravaidyaMichael L Shuler
Nov 19, 2005·The Biochemical Journal·Richard J OrtonWalter Kolch
Jan 13, 2006·Nature Chemical Biology·C Geoffrey BurnsMark C Fishman
Apr 8, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Nicola LongoMarzia Pasquali
Jun 27, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Patrice GonzalezJean-Paul Bourdineaud
Oct 24, 2007·Biochemical and Biophysical Research Communications·Camilla PramfalkPaolo Parini
Apr 15, 2008·Toxicology and Applied Pharmacology·Xiongjie ShiBingsheng Zhou
May 24, 2008·Molecular Cell·William G Kaelin, Peter J Ratcliffe
May 29, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wojciech Jelski, Maciej Szmitkowski
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
May 29, 2009·Journal of Clinical Pathology·R Ramachandran, S Kakar
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Trista E NorthWolfram Goessling
Mar 8, 2011·Cytokine & Growth Factor Reviews·Markus F Neurath, Susetta Finotto
Jun 4, 2011·Toxicologic Pathology·Aswin L MenkeRuud A Woutersen
Feb 1, 2003·Environmental Toxicology and Pharmacology·Ron van der OostNico P E Vermeulen
Jul 26, 2011·Biochimica Et Biophysica Acta·Colin Watts
Jan 1, 2011·Frontiers in Immunology·Arnaud M LabrousseIsabelle Maridonneau-Parini
Jul 14, 2012·Small GTPases·Timothy D Martin, Channing J Der
Feb 12, 2013·Ecotoxicology and Environmental Safety·Tatiana S PereiraVera M F Vargas
May 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer B DennisonGordon B Mills
Oct 23, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anja-Maria MöllerHelmut Segner
Feb 26, 2014·Zebrafish·Giorgia GioacchiniOliana Carnevali
Apr 30, 2014·British Journal of Clinical Pharmacology·A D Bastiaan VliegenthartJames W Dear
Jun 1, 2014·Virchows Archiv : an International Journal of Pathology·Antonio Lopez BeltranEva Comperat
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tina FløyelFlemming Pociot
Jul 10, 2014·Environmental Monitoring and Assessment·Shirin RahmanpourSeyede Masoumeh Lotfi Ashtiyani

❮ Previous
Next ❯

Citations

Nov 15, 2020·International Journal of Molecular Sciences·Zhaodong LiFan Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.