Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid

Free Radical Research
Christopher J L SilwoodM Grootveld

Abstract

High field 1H NMR spectroscopy demonstrated that addition of Co(II) ions to osteoarthritic knee-joint synovial fluid (SF) resulted in its complexation by a range of biomolecules, the relative efficacies of these complexants/chelators being citrate > histidine - threonine > glycine - glutamate - glutamine - phenylalanine tyrosine > formate > lactate > alanine > valine > acetate > pyruvate > creatinine, this order reflecting the ability of these ligands to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their SF concentrations. Since many of these SF Co(II) complexants (e.g. histidinate) serve as powerful *OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via Fenton or pseudo-Fenton reaction systems will be "site-specifically" scavenged. The significance of these observations with regard to cobalt toxicity and the in vivo corrosion of cobalt-containing metal alloy joint prostheses (e.g. CoCr alloys) is discussed.

References

Nov 15, 1989·Archives of Biochemistry and Biophysics·M B KadiiskaR P Mason
Aug 1, 1988·FEBS Letters·J D BellP J Sadler
Aug 28, 1998·Journal of Inorganic Biochemistry·S LeonardX Shi
Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A Z DamyanovichK W Marshall
Jan 13, 2000·Toxicology and Applied Pharmacology·G RoesemsB Nemery
Apr 15, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·V HerynekR A Brooks
Aug 4, 2001·Toxicology and Applied Pharmacology·J S Fedan, D Cutler
Feb 28, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Christopher L SilwoodEdward Lynch
Apr 30, 2002·Free Radical Biology & Medicine·Shosuke KawanishiShinji Oikawa
May 9, 2002·Journal of Toxicology and Environmental Health. Part a·Alexander PilgerWolf Osterode
May 9, 2002·Journal of Toxicology and Environmental Health. Part a·Sabine IvancsitsHugo W Rüdiger

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Citations

Mar 10, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christopher J L Silwood, Martin Grootveld

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