PMID: 6163735Jan 1, 1981Paper

Investigation of the possible involvement of IgE anti-salicyloyl antibodies in patients with urticaria

International Archives of Allergy and Applied Immunology
S KrilisB A Baldo

Abstract

19 aspirin-sensitive and 14 non-aspirin-sensitive patients with chronic urticaria were tested for the presence of specific anti-salicyloyl-IgE antibodies by prick testing, RAST and in vitro histamine release using an aspirin-polylysine conjugate. Polylysine succinate served as a control. Negative results were obtained in all cases with the exception of 1 patient who gave a positive prick test response. However, this patient reacted to the control conjugate as well as aspirin polylysine. Skin prick test responses to the battery of environmental allergens revealed that the majority (90%) of the aspirin-sensitive patients were non-atopic. The findings suggest that the clinical symptoms and signs in patients with chronic urticaria associated with aspirin sensitivity are not mediated by specific IgE antibodies.

Citations

Feb 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ronald A Simon, Donald D Stevenson
Mar 26, 2003·Clinical and Experimental Dermatology·C E H Grattan
Jun 25, 1987·The New England Journal of Medicine·L B SchwartzT Sullivan

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