Investigation of the potential endocrine effect of nitrate in zebrafish Danio rerio and brown trout Salmo trutta

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Poul BjerregaardHenrik Holbech

Abstract

Nitrate has the potential to affect steroid production. Nitrate concentrations in streams in agricultural areas may exceed concentrations showing effects in laboratory studies. The effects of nitrate and/or nitrite on endocrine relevant endpoints were tested in zebrafish and brown trout. Zebrafish were exposed in two experiments to nitrate (8.8 to 89 mg NO3-/L) and nitrite (3.6 to 19 mg NO2-/L) during the period of sexual differentiation and sex ratios were determined. Vitellogenin concentrations were determined in the second experiment. The sex ratio was unaffected by the exposure to nitrate and nitrite. Vitellogenin concentrations were slightly elevated in males (but not females) in all of the groups exposed to nitrate. Juvenile brown trout were exposed to 5.7, 14, and 31 mg NO3-/L for 8 days and vitellogenin levels in liver were determined. Vitellogenin concentrations in the females were not affected by exposure, but in the males, there was an overall statistically significant effect of exposure to nitrate with the group exposed to 5.7 mg NO3-/L showing a trend of higher vitellogenin concentrations than the control group; levels in the males of the groups exposed to 14 and 31 mg NO3-/L were not statistically different from t...Continue Reading

Citations

Mar 25, 2020·International Journal of Environmental Research and Public Health·Luke R IwanowiczJohn Abatemarco
Aug 17, 2020·Ecotoxicology and Environmental Safety·Rita CofoneIda Ferrandino
May 30, 2021·Environmental Pollution·ZhiChao DangAude Kienzler

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