Investigation of the release behavior of a covered-rod-type formulation using silicone

Journal of Controlled Release : Official Journal of the Controlled Release Society
Hiroo MaedaYuji Kurosaki

Abstract

The purpose of this study was to investigate the effects of the properties of a drug on its release behavior in a cylindrical sustained-release formulation having a two-component structure, with a silicone matrix containing drug powder as the inner layer component, and with its lateral side covered with an silicone outer layer (CR silicone formulation). In this study, the release profile of a drug from "the lateral side covered with silicone" and from "the cross-sections where the inner layer is exposed to the surface" was examined using a newly designed bi-directional elution cell. The relationships between the release profile and solubility of the drug and its permeability through silicone were also studied. Bovine serum albumin (BSA), antipyrine (ANP), indometacin (IDM) and ketoprofen (KP) were used as model drugs. Each CR silicone formulation containing drug powder consisting of a drug and sucrose (SUC) was investigated, and a satisfactory relationship was observed between drug release from the cross-sections and drug solubility, and between drug release from the lateral side and permeability of the drug through a silicone membrane. For CR silicone formulations containing IDM, the addition of deoxycholate sodium (DOC) impro...Continue Reading

References

Dec 1, 1990·Chemical & Pharmaceutical Bulletin·T HatanakaY Morimoto
Aug 26, 1983·Science·W C CampbellT A Jacob
Apr 18, 2000·International Journal of Pharmaceutics·M IervolinoJ Hadgraft
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·M KajiharaY Urabe
Oct 26, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miho MaedaToshiki Yoshimine

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Citations

Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiroo MaedaYuji Kurosaki
Oct 5, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magdalena Prokopowicz
Sep 25, 2014·Expert Opinion on Drug Delivery·Ravi VaishyaAshim K Mitra
Jan 21, 2016·Drug Delivery and Translational Research·Diarmaid J MurphyR Karl Malcolm
May 21, 2015·Biomedical Materials·Locke Davenport HuyerMilica Radisic
Nov 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ryan J MorrowR Karl Malcolm

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