Jun 1, 1996

Investigation of the RH locus in gorillas and chimpanzees

Journal of Molecular Evolution
C M Westhoff, D E Wylie

Abstract

The human Rh blood-group system is encoded by two homologous genes, RhD and RhCE. The RH genes in gorillas and chimpanzees were investigated to delineate the phylogeny of the human RH genes. Southern blot analysis with an exon 7-specific probe suggested that gorillas have more than two RH genes, as has recently been reported for chimpanzees. Exon 7 was well conserved between humans, gorillas, and chimpanzees, although the exon 7 nucleotide sequences from gorillas were more similar to the human D gene, whereas the nucleotide sequences of this exon in chimpanzees were more similar to the human CE gene. The intron between exon 4 and exon 5 is polymorphic and can be used to distinguish the human D gene from the CE gene. Nucleotide sequencing revealed that the basis for the intron polymorphism is an Alu element in CE which is not present in the D gene. Examination of gorilla and chimpanzee genomic DNA for this intron polymorphism demonstrated that the D intron was present in all the chimpanzees and in all but one gorilla. The CE intron was found in three of six gorillas, but in none of the seven chimpanzees. Sequence data suggested that the Alu element might have previously been present in the chimpanzee RH genes but was eliminated ...Continue Reading

  • References20
  • Citations14

References

  • References20
  • Citations14

Mentioned in this Paper

Exons
Genome
Antigen D, Rh Blood Group
Genes, Reiterated
Recombination, Genetic
Gene Deletion
Gorilla <Eastern Gorilla>
Phylogeny
Southern Blot Result
Pan troglodytes

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