Investigation of the role of the GABRG2 gene variant in migraine

Journal of the Neurological Sciences
Timothy ChenL R Griffiths

Abstract

Migraine is the most common neurological disorder worldwide affecting about 12% of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GABAA gene encodes for the GABAA receptor. Along with other receptors, the GABAA receptor is involved in the mediation of neuronal activities. In this study, a GABRG2 gene (GABAA receptor gamma-2-subunit) SNP (rs211037) was genotyped on a migraine case-control population of 546 (273 affected and an equal number of healthy) individuals. Using specifically designed primers, a high resolution melt (HRM) assay was carried out in the genotyping process. After genotyping, results were compared in the case and control populations. Analysis of results showed no significant differences in the allele frequencies between case and control populations. Similarly no differences were detected for subtypes or for a specific gender of migraine (p>0.05). Although this gene has been previously found to be involved in febrile seizures and there is some co-morbidity between epilepsy and migraine, we decided to investigate this marker for involvement in mig...Continue Reading

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Citations

Jul 3, 2013·The Journal of Headache and Pain·Luana LionettoPaolo Martelletti
Jul 13, 2017·Headache·Elena García-MartínFélix Javier Jiménez-Jiménez
Jan 5, 2018·Journal of Neural Transmission·Elena García-MartínFélix Javier Jiménez-Jiménez
Jul 19, 2018·The Journal of Headache and Pain·Adina BathelTobias Schmidt-Wilcke

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