PMID: 6409996Jun 1, 1983Paper

Investigation of the system copper(II) carbonic anhydrase and HCO3-/CO2

Journal of Inorganic Biochemistry
I BertiniE Borghi

Abstract

Copper(II) substituted human and bovine carbonic anhydrases B in the presence of bicarbonate have been investigated in solution through water-solvent proton nuclear magnetic resonance (nmr) at variable magnetic fields. HCO3-, contrary to all the other monoanionic inhibitors, partially reduces the water proton relaxation rates. This has been accounted for on the basis of the availability within the active cavity of two coordination positions partially overlapping. 13C-nmr measurements on both CO2 and HCO3- confirm that HCO3- binds the metal, whereas CO2 interacts with the paramagnetic center at nonbonding distance. The upper limit for the CO2 in equilibrium HCO3- interconversion has been estimated to be 10 sec-1.

References

Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P L YeagleR W Henkens
Oct 1, 1975·Archives of Biochemistry and Biophysics·L MorpurgoB Mondovì
Jul 17, 1973·Biochemical and Biophysical Research Communications·S H Koenig, R D Brown
Dec 31, 1973·Annals of the New York Academy of Sciences·S H Koenig, R D Brown
Apr 8, 1960·Biochimica Et Biophysica Acta·S LINDSKOG

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Citations

Nov 19, 1991·Biochemistry·R S AlexanderD W Christianson
Nov 25, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·José Malanho SilvaVito Calderone
Dec 9, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Linda CerofoliniClaudio Luchinat

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