Investigation of three oncogenic epitheliotropic viruses shows human papillomavirus in association with non-melanoma skin cancer

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Camila Freze BaezRafael B Varella

Abstract

Non-melanoma skin cancers (NMSC) share similar risk factors with other virus-related cancers, despite the lack of proved causal association between viral infection and NMSC development. We investigated the presence of Merkel cell polyomavirus (MCPyV), Epstein-Barr virus (EBV), and human papillomavirus (HPV) DNA in 83 NMSC fresh-frozen and 16 non-cancerous skin biopsies and evaluated viral infection according to demographical data, histopathological diagnosis, and ultraviolet exposure. Our results showed that 75% of NMSC biopsies were positive for at least one out of three viruses, whereas only 38% of non-cancerous skin biopsies were positive (p = 0.02). Notably, HPV detection was frequent in NMSC (43%) and nearly absent (one sample, 6.7%) in non-cancerous biopsies (p = 0.007). MCPyV was associated with sites of higher exposure to ultraviolet radiation (p = 0.010), while EBV was associated with a compromised immune system (p = 0.032). Our study showed that HPV was strongly associated with NMSC while EBV and MCPyV with other risk factors. Though further studies are required to elucidate the role of viral infection in NMSC development and management, this study supports the possible role of oncogenic viruses in skin cancers, espec...Continue Reading

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Citations

Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Balint CsobozUgo Moens
May 6, 2020·Head & Neck·Ulrich MoserDietmar Thurnher
Oct 16, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cal RobinsonAbhijat Kitchlu

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Methods Mentioned

BETA
biopsies
biopsy
electrophoresis
genotyping

Software Mentioned

SPSS statistics

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